Faculty Directory

Contact Information

Office:
Life Sciences & Bioengineering Center, 4010
Phone: +1-508-831-6742
Fax: +1-508-831-5541
gpins@wpi.edu

George D. Pins

The overall objective of my research is to create bioengineered scaffolds to enhance the regeneration of damaged tissues and organs. Specifically, my laboratory uses biomimetic design strategies and novel fabrication processes to develop three-dimensional constructs that emulate native tissue architecture and cellular microenvironments. We use these scaffolds to characterize the roles of extracellular matrix (ECM) cues and topographic features in modulating cellular functions, including adhesion, migration, proliferation, differentiation, and tissue remodeling. For example, we are investigating the design of microfabricated basement membrane structures to direct keratinocyte function and enhance the performance of bioengineered skin substitutes. We are also designing novel biopolymer microthreads that are being used to deliver stem cells and to facilitate myocardial or skeletal muscle regeneration. These scaffolds have been used, as well, to develop in vitro model systems to predict cellular and tissue responses to implantable biomaterials for the repair of soft tissues including tendon and ligament.

In the classroom, I enjoy teaching students about the fundamentals of biomaterials science and cell-biomaterial interactions used to design implantable biomaterials that promote functional tissue restoration. I particularly enjoying working with teams of students on capstone design projects to develop biomaterials scaffolds and benchtop assays to characterize cell-biomaterial interactions that can be used to solve clinical problems related to wound healing and tissue regeneration. At the graduate level, I enjoy mentoring master’s and doctoral students; helping them develop into independent scientists and engineers who will contribute to solutions of various healthcare problems. 

Research Interests

  • Biomaterials
  • Cell-biomaterial interactions
  • BioMEMs
  • Wound healing
  • Tissue regeneration

Education

  • BS, Rutgers University, 1989
  • PhD, Rutgers University, 1996
  • Post-doc, MGH, Harvard Medical School, 1999
  • Staff Scientist, Molecular Geodesics, Inc., 2000

Featured Publications

  • Cornwell, K.G., Pins, G.D., "Enhanced Proliferation and Migration of Fibroblasts on the Surfaces of FGF-2 Loaded Fibrin Microthreads" for Tissue Engineering, 2010, Aug 28 {epub ahead of print}
  • Bush, K.A., Pins, G.D. "Carbodiimide-Fibronectin Conjugation Strategy Enhances Regenerative Capacity of Collagen Basal Lamina Analogs", Tissue Eng Part A., 16(3):829-38, 2010
  • Proulx, M. K., Carey, S. P., DiTroia, L. M., Jones, C. M., Fakharzadeh, M., Orr, R., Guyette, J. P., Blackwood, A., L., Rolle, M., R., Pins, G. D., Gaudette, G, R., “Fibrin Microthreads Support Mesenchymal Stem Cell Growth While Maintaining Differentiation Potential”, J. Biomed. Mat. Res Feb;96(2):301-12 (2011).
  • Bush, K.A., Driscoll, P., Soto, E., McGimpsey, W.G., Pins, G. D., "Designing Tailored Biomaterials Surfaces to Direct Keratinocyte Morphology, Attachment and Differentiation", J. Biomed. Mat. Res., 90 (4):999-1009 (2009)
  • Pai, S., Dunn, R.M., Babbitt, R., Strom, H., Pins GD, Lalikos, J., and Billiar, K.,, “Characterization of forces on the sternal midline following median sternotomy in a porcine model.”, J Biomechanical Engineering, 130: (2008)

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