BIOLOGY & BIOTECHNOLOGY SEMINAR:
"Yeast actin cable length control and formin regulation by conserved mechanisms"
Dr. Julian Eskin, Ph.D.
Host: Assistant Professor Amity Manning
Actin networks of diverse shapes and sizes support numerous cellular processes, including migration, transport, and cytokinesis. Formins potently stimulate the nucleation and elongation of actin polymers, and are tightly controlled spatially and temporally to maintain actin structures with appropriate geometries. To understand this control, we have dissected the mechanisms governing S. cerevisiae actin cable assembly. Specific sequences in the formin inhibitor Smy1 mediate regulation of the formin Bnr1 in vitro, and this inhibition is critical in vivo for maintaining proper actin cable length, shape, and velocity. Using homology searching, we have found other proteins across evolutionarily distant species that appear to use related sequence motifs to regulate formin function. These results have exposed unanticipated similarities in diverse formin-regulatory mechanisms, and provide new insights into how cells tune the shapes and architectures of their actin networks.
Tuesday, December 13, 2016 @ 4:15 pm