BIOLOGY & BIOTECHNOLOGY SEMINAR:
" Molecular and Cellular Mechanisms of Active Forgetting "
~ BBT Neurobiology Faculty Candidate ~
Isaac C. Sandoval, Ph.D.
Depart of Neuroscience
Scripps Research Institute
Forgetting, one part of the brain’s memory management system, provides balance to the encoding and consolidation of new information by removing unused or unwanted memories or by suppressing their expression. Recent studies identified the small G-protein, Rac1, as a key player in the Drosophila mushroom bodies neurons (MBn) for, active forgetting. We subsequently discovered that a few dopaminergic neurons (DAn) that innervate the MBn mediate forgetting. We then showed that Scribble, a scaffolding protein known primarily for its role as a cell polarity determinant, orchestrates the intracellular signaling for normal forgetting. Knocking down scribble expression in either MBn or DAn impairs normal memory loss. Scribble interacts physically and genetically with Rac1, Pak3 and Cofilin within MBn, nucleating a forgetting signalosome that is downstream of dopaminergic inputs that regulate forgetting. These results bind disparate molecular players in active forgetting into a single signaling pathway: Dopamine⇒Dopamine Receptor⇒Scribble⇒Rac⇒Cofilin.
Tuesday, February 12, 2019 @4:15 p.m.