BIOLOGY & BIOTECHNOLOGY
Undergraduate Teaching Talk
"Behavioral State Regulation of Active Forgetting"
~ BBT Neurobiology Faculty Candidate ~
Isaac C. Sandoval, Ph.D.
Department of Neuroscience
Scripps Research Institute
Pioneering research studies, beginning with those using Drosophila, have identified several molecular and cellular mechanisms for active forgetting. The currently known mechanisms for active forgetting include neurogenesis-based forgetting, interference-based forgetting, and intrinsic forgetting, the latter term describing the brain’s chronic signaling systems that function to slowly degrade molecular and cellular memory traces. Recently, in Drosophila, the ongoing activity of specific dopamine neurons was shown to regulate the forgetting of olfactory memories. This ongoing dopaminergic activity is modulated with behavioral state, increasing robustly with locomotor activity and decreasing with rest. Therefore, forgetting is regulated by the behavioral state modulation of dopaminergic-based plasticity. These findings integrate psychological and neuroscience research on sleep and forgetting.
Pizza and beverages will be served!
Wednesday, February 13, 2019 from 12:00-1:00 p.m.