University of Texas at Arlington
Abstract: Diffuse optical imaging (DOI), also referred to as functional near-infrared spectroscopy (fNIRS), is an emerging technology that has received increasing attention in recent years because it is safe, portable and relatively low-cost. It uses near-infrared light between 650-900 nm to penetrate the tissues. The light is primarily absorbed by oxygenated and deoxygenated hemoglobin, and cytochrome c oxidase. Therefore, it is sensitive to the changes in cerebral hemodynamics and metabolism. This technology has now reached a tipping point where users are exploring its potential for a wide range of health science and clinical applications. The NeuroPhotonics Lab (NPL) at the University of Texas at Arlington has been dedicated to methodological development in this field towards better image quality and more robust signal detection. Most recently, we have combined DOI with low-level transcranial laser stimulation (TLS) for optimized and personalized therapy. This noninvasive, imaging-guided neuromodulation has great therapeutic potentials for various neurological diseases such as posttraumatic stress disorder (PTSD), major depression, traumatic brain injury (TBI), and neurodegenerative diseases.