BME Seminar Series: “Boundary Lubricating Properties (and more) of PRG4/Lubricin on Articular Cartilage, the Ocular Surface, and other Biomaterials & Biointerfaces” by Tannin Schmidt, PhD, School of Dental Medicine, UConn Health

Monday, December 03, 2018
4:00 pm to 5:00 pm
Floor/Room #: 
GP1002

Tannin Schmidt, PhD
Department of Biomedical Engineering
School of Dental Medicine, University of Connecticut Health Center
Associate Professor

 

Abstract:
 
Proteoglycan 4 (PRG4), also known as lubricin, is a mucin-like glycoprotein found throughout the body in various tissues and fluids, classically defined by its boundary lubricating properties.
The overarching goal of this work is to understand the fundamental mechanisms and properties of PRG4, also known as lubricin (a critical lubricating protein found throughout the human body, recently discovered to also have anti-inflammatory properties), at relevant biointerfaces and biomaterials, and to apply that knowledge to the development of recombinant human PRG4-containing biotherapeutics and biomaterials. To accomplish this biomechanical, biochemical, and biophysical methods are employed in collaboration with biologists, engineers, and clinicians.
Four current objectives of this work are: 1) elucidating the molecular basis of synovial fluid’s articular cartilage boundary lubricating function, and providing the framework for development of PRG4-containing OA biotherapeutics; 2) understanding PRG4’s role on the ocular surface, and characterizing/developing novel PRG4-containing contact lens biomaterials and artificial tears for the treatment of dry eye disease; 3) assessing PRG4’s potential as a boundary lubricant of biomaterials for a variety of other clinical applications; 4) examining PRG4’s biological properties and its potential as a therapeutic treatment of a variety of inflammatory conditions, tissue adhesions, and cancer.
 
Biography: Dr. Tannin Schmidt is an Associate Professor in the Biomedical Engineering Department, School of Dental Medicine, at the University of Connecticut Health Center. Dr. Schmidt's research interests in bioengineering lie within biomaterials, biomechanics, biotribology, and biochemistry. The goal of his research program is to understand the fundamental mechanisms and properties of PRG4, also known as lubricin (a critical lubricating protein found throughout the human body, recently discovered to also have anti-inflammatory properties), at relevant biointerfaces and biomaterials, and to apply that knowledge to the development of PRG4-containing biotherapeutics and biomaterials.
Dr. Schmidt received his BASc in Engineering Science from the University of Toronto in 2000, then his MS and PhD in Bioengineering from the University of California San Diego in 2002 and 2006, respectively. He then completed a post-doctoral fellowship in the Department of Biochemistry at Rush University Medical Center, Chicago. Prior to moving to UConn in 2017, Dr. Schmidt spent 9+ years at the University of Calgary. He is also a scientific co-founder of a clinical stage biotech company Lubris BioPharma, LLC, that recently out licensed their recombinant human lubricin to Novartis for ophthalmic indications worldwide (outside Europe) including the treatment of dry eye. Lubris continues to evaluate other clinical applications including but not limited to osteoarthritis, dry mouth, and post-surgical adhesions.
DEPARTMENT(S): 
Name: 
Department of Biomedical Engineering
Phone Number: