BME Seminar Series: "Development Inspired Design: Connecting Mechanical and Molecular Regulators of Development to Direct Self-Assembly of Tissues" by Jason Gleghorn, Ph.D, Assistant Professor, Department of Biomedical Engineering, University of Delaware

Monday, April 01, 2019
12:00 pm to 1:00 pm
Floor/Room #: 
Jason Gleghorn, Ph.D.
Department of Biomedical Engineering
University of Delaware
Assistant Professor
Abstract: Development of the lung, like many other organs is highly regulated spatially and temporally, leading to an architecture that is important for its ultimate function. I will discuss the use of our novel microfluidic platforms for the culture of embryonic mouse lung explants and their use in uncovering mechanically responsive signaling molecules for several key reciprocal molecular signaling pathways between the epithelium, mesenchyme, and mesothelium that are responsible for regulation of airway morphogenesis. Further, I will discuss or efforts to apply what we have learned about how the embryo assembles organs into approaches for the creation of large scale tissues in the dish via a “directed” self-assembly approach. We believe this combination of techniques combined with what we learn in our studies of the native cellular behaviors and interactions in the embryo can be used to define new therapeutic approaches for regenerative medicine.
Biography: Dr. Jason Gleghorn earned a Ph.D. in soft tissue mechanics from Cornell University and subsequently completed postdoctoral fellowships in molecular and developmental biology and microfluidics at Princeton University and Cornell University respectively. He is currently an Assistant Professor at the University of Delaware.  Dr. Gleghorn holds faculty appointments in the Departments of Biomedical Engineering, Mechanical Engineering, and Biology and he is the Director of the Tissue Morphodynamics and Regenerative Medicine Laboratory.  His lab develops and uses microfluidic and microfabrication technologies to determine how cells behave and communicate within multicellular populations to form complex 3D tissues and organs. Dr. Gleghorn is the recipient of the ORAU Ralph E. Powe Award, the March of Dimes Basil O’Connor Award, the University of Delaware Bernard Canavan Early Career Research Award, and he has been named a Cellular and Molecular Bioengineering Rising Star from the Biomedical Engineering Society and a Cell and Molecular Bioengineering Young Innovator from the CMBE Journal.
Department of Biomedical Engineering
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