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BME Seminar Series: "Lipid-Based Systems: From Therapeutics To In Vitro Models" by Christina M. Bailey-Hytholt, Ph.D| Assistant Professor| Chemical Engineering

Monday, October 24, 2022
12:00 pm to 12:50 pm
Floor/Room #: 
Christina Bailey-Hytholt, PhD 
Assistant Professor  
Department of Chemical Engineering
Worcester Polytechnic Institute 





Abstract: Lipid constructs are ubiquitous and advancing healthcare technologies through advancements in therapeutics and in vitro model systems. Lipid nanoparticles (LNPs) and liposomes serve as delivery vehicles for nucleic acids and small molecules by improving transfection efficiency, targeting, and stability of their loaded cargo. Additionally, lipid structures, including lipid vesicles and lipid bilayers, are useful tools to understand molecular interactions at biological interfaces. This talk will discuss strategies for using lipids for both therapeutic and in vitro model applications. Methods to manufacture LNPs and liposomes, characterization, and in vitro studies will be discussed for messenger RNA (mRNA) and plasmid DNA (pDNA) loaded LNPs and antifungal loaded liposomes. Additionally, this talk will discuss the formation and use of multi-lipid bilayers representative of placental trophoblast lipid bilayers for pharmaceutical and environmental toxicant interaction studies.

Biography: Dr. Christina Bailey-Hytholt is an Assistant Professor of Chemical Engineering at Worcester Polytechnic Institute. Her research focuses on designing biomaterials for applications in drug and gene delivery, in vitro model systems, and diagnostics with a broad interest in applications for women’s health. She is the recipient of several honors and awards for both her research and teaching, including a Career Development Award from the Biomedical Engineering Society and a Women in Chemical Engineering Travel Award from the American Institute for Chemical Engineers. Most recently, Dr. Bailey-Hytholt was selected as one of Forbes’ 30 under 30 in Science for 2022. Prior to joining WPI, Dr. Bailey-Hytholt was a Postdoctoral Fellow in the Biologics Drug Product Development & Manufacturing group at Sanofi. She received her Ph.D. in Biomedical Engineering from Brown University in 2020 as an NSF Graduate Research Fellow, and she was awarded Brown University’s Presidential Award for Excellence in Teaching as well as Brown University’s School of Engineering Outstanding Thesis Award. She received her B.S. in Chemical Engineering at WPI in 2015.

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