Development of new strategies to treat antibiotic-resistant infections
Dan Kahne, Ph.D.
Higgins Professor of Chemistry and Chemical Biology and of Molecular and Cellular Biology
Professor of Biological Chemistry and Molecular Pharmacology
Department of Chemistry and Chemical Biology
Host: Robert Dempski, Ph.D.
This talk will focus on the biogenesis of the cell envelope of Gram-negative bacteria. The assembly of this organellar membrane must be accomplished outside the cell in the absence of an obvious energy source. My research focuses on identifying and understanding the machinery necessary for proper assembly of this membrane barrier, as well as the mechanisms that lead to defects. Because the outer membrane creates an effective permeability barrier to most antibiotics, understanding how to interfere with its assembly could provide new targets for antibiotic discovery.