Copper-Catalyzed Oxidative Decarboxylative Coupling Reactions
Jessica M. Hoover, Ph.D.
West Virginia University,
Host: Marion Emmert, Ph.D.
Decarboxylative coupling reactions are emerging as an efficient route to access a diverse array of substituted arenes from inexpensive and readily available precursors. Unfortunately, most methods require pre-functionalized aryl halide coupling partners. An oxidative transformation enabling the direct decarboxylative coupling with an arene C-H bond is an attractive alternative, but current methodologies suffer limitations of substrate scope. Copper catalysts offer an opportunity to overcome these challenges, yet there are limited examples of a Cu-catalyzed transformation of this type. This talk will focus on our recently developed copper-catalyzed oxidative decarboxylative C-H arylation reaction to generate biaryl products. Recent work to extend the scope of reactivity, explore the reaction mechanism, and understand the substrate limitations will also be presented.