Design and Development of Novel Antibiotics via Marine Natural Products
Sivappa Rasapalli, Ph.D.
Host: José Argüello, Ph.D.
With microbial drug resistance beginning to erode the usefulness of our most important antibiotics, there is once again a critical need to discover new drugs to combat these evolving pathogens. The study of secondary metabolites produced by microorganisms has to date been the most successful strategy for the development of medically useful antibiotics. Rasapalli Research Group is engaged in marine natural products based medicinal chemistry. Results from projects exploring structural analogues of oroidin, a guanidine secondary metabolite from marine sponges, for the SAR studies through imidazopyrimidine chemistry will be presented. In addition, the synthesis and characterization of derivatives of ansamacrolides isolated from Streptomyces sp. will be described.