This talk presents some new frontiers for biomaterials and bio-inspired design. It is divided into three parts. In the first part of the talk, some novel concepts are presented for the development of bionic structures. These include tissue engineered structures that can detect radio-frequency signals that could enable future bionic hearing. The implications of the work are discussed for the development of the next generation of tissue engineered structures. In the second part of the talk, turtle shell structures are used as sources for the design of energy-absorbing structures. The layered structure of turtle shells is studied using a combination of microscopy, indentation and deformation experiments. A combination of analytical and computational models is then used to simulate the contact-induced deformation of three-layered turtle shell structures. The implications of the results are discussed for the design of protective energy-absorbing structures. Finally, in the third part of the talk, nanoparticle concepts are presented for the specific detection and treatment of breast cancer. These include ligand-conjugated gold and magnetite nanoparticles that can be used to target specific over-expressed receptors on the surfaces of breast cancer cells. A combination of adhesion force measurements, thermodynamics and kinetics models is used to explain the receptor-meditated endocytosis of ligand-conjugated nanoparticles into breast cancer cells/tissue. Ligand-conjugated magnetite nanoparticles are also shown to enhance the magnetic resonance imaging (MRI) of breast tumors and their metastases, while gold/drug nanoclusters or magnetite/drug nanoclusters are shown to have the potential for future applications in theranostics and future cancer surgery.
Wole Soboyejo received a BSc in mechanical engineering from King’s College London in 1985. He then went on to Cambridge University where he obtained his PhD in materials science in 1988. Between 1988 and 1992, he was as a Research Scientist at the McDonnell Douglas Research Labs. In 1992, he was a Principal Engineer at the Edison Welding Institute before joining the Department of Materials Science and Engineering at The Ohio State University, where he worked from 1992 until 1999. Between 1997 and 1998, he was a Visiting Martin Luther King Associate Professor at MIT. Soboyejo was appointed as a Professor of Mechanical and Aerospace Engineering at Princeton University between 1999 and 2016. He also served as the President and Provost of the African University of Science and Technology in Abuja, Nigeria, from 2012 to 2014. Soboyejo was appointed as Dean of Engineering at WPI in September, 2016. He is the recipient of National Young Investigator Awards from the NSF and the ONR. He is also a recipient of ASM’s Bradley Stoughton Award for excellence in the teaching of materials science, the Lumley Research Award from The Ohio State University, and Princeton’s Old School Award for Research and Innovation. Soboyejo is a Fellow of ASME and the Nigerian Academy of Science. He is the author of 3 textbooks and 370 journal papers.