Technologies for Biosensing Applications
Lab-on-chip and implantable sensor systems have been widely sought as a means to provide long term minimally invasive, portable, and low cost sensing solutions. The microbioelectronics lab at the University of Tennessee Knoxville, combines advanced microfabrication techniques with CMOS readout to enable the development of low cost sensing systems. Glucose monitoring systems combined with insulin pumps and control algorithms can act as an artificial pancreas device system. Key challenges of an artificial pancreas system implementation include improving glucose sensor sensitivity at microscale, integrating electrodes with low-power and low-noise readout, modeling and predicting glucose fluctuations with patient’s dynamic physiological conditions and implementing complex algorithms to mimic natural glucose regulation. In this talk, we will present on our development of a two-chip CMOS-vertically aligned carbon nano-fiber based glucose sensing system and a low-power instrument for continuous physiological data extraction from bowel sounds. Together these systems can be integrated into an artificial pancreas device system. We will discuss some of the challenges in integrating CMOS readout electronics and the nano-structures and explore some of the techniques for optimizing these systems.
Nicole McFarlane received her received the B.S. and M.S. degrees in Electrical Engineering from the Howard University, Washington DC, in 2001 and 2003 respectively, and her Ph.D. in Electrical Engineering at the University of Maryland, College Park, in 2010. In the summers of 2000 and 2001 she worked as an electrical engineering intern at the Millstone Nuclear Power Plant. From 2001 to 2003 she worked as a Graduate Research Assistant at the Materials Science Research Center of Excellence at Howard University, characterizing IIIV- Nitrides. From 2003 to 2010 she worked as a Graduate Research Assistant in the Integrated Biomorphic Information Systems Laboratory at the Institute for Systems Research of the University of Maryland. Her work focused on understanding information and power efficiency trade-offs in mixed-signal integrated circuit design, CMOS biosensors, and on CMOS/MEMS integration for lab-on-a-chip technologies.
Since 2010, she has been an Assistant Professor at the University of Tennessee working on circuits and devices for sensing systems. Her main research includes carbon nanostructures and CMOS based solutions. Additionally, while at the University of Tennessee she has done significant outreach and mentoring to underrepresented groups at the, high school, undergraduate, and graduate levels. She currently serves on the Biomedical and Life Science Circuits and Systems and the Sensory Systems Technical Committees and served on the Organizing Committee for ISCAS 2017.
Host: Professor John McNeill