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Microbial Fermentation Development, Scale-up, and Manufacturing - WPI Biomanufacturing Education and Training Center

Tuesday, June 09, 2020 to Friday, June 12, 2020
8:00 am to 4:00 pm
Biomanufacturing Education & Training Center
50 Prescott Street
Worcester, MA 01609
United States
Floor/Room #: 
Biomanufacturing Education and Training Center

The successful implementation of microbial fermentation technology requires optimization of a number of variables. A clear understanding of all aspects of this technology assures that upstream scientists and technicians are capable and confident in their handling of these processes.

This course employs extensive hands-on laboratory work using both single-use and stainless steel equipment. Participants will thaw seed vials and perform scale-up operations from a shake flask to a bench top fermenter, to a pilot scale fermenter. Participants will also learn the fundamentals of microbial growth, cell line development and media composition and selection.


  • Understand the principles of microbial growth and growth kinetics
  • Understand what the various media components are and their functionality
  • Understand protein expression and production
  • Identify the critical components of fermenters: how they work and are used
  • The setup, preparation, sterilization and inoculation of a fermenter
  • Understand how mixing studies are performed and why
  • Understand the critical attributes to consider during scale-up
  • Define the procedures employed to harvest the fermenter
  • Learn the above in a simulated GMP environment following SOPs

This class is limited to 24 students – reserve your seat early to avoid being waitlisted.


  • Program Start:  June 9-12, 2020
  • Registration Deadline:  two weeks prior to program start
  • Time: 8:00 a.m.to 4:00 p.m.
  • Location: Biomanufacturing Education & Training Center (BETC)
    WPI Gateway Park 2, 50 Prescott Street (2nd floor) Worcester, MA
  • Price: $3,900
  • CEU: 2.8

There are no academic prerequisites for this program.

Who Should Attend

  • Biomanufacturing associates and operators involved in upstream operations
  • Biomanufacturing associates and operators currently trained in cell culture operations who want to become proficient in microbial fermentation
  • Biomanufacturing associates and operators involved in downstream processing who want to become cross-trained in fermentation
  • Project and program managers for equipment and material vendors that serve the biotechnology industry
  • Quality assurance personnel responsible for the review of upstream process documentation
  • Technical writers responsible for generating batch records and recipes
  • Process development associates
  • Research scientists
  • Bioprocess engineers
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