Lennox (John) Hoyte ’79 grew up in Trinidad, watching his mother—a registered nurse-midwife—care for women and deliver their babies, sometimes in the family’s home. The way she tended to the needs of each individual made a deep impression on him. It was her dream to have a son who would grow up and become a physician.
Instead, Hoyte became an engineer—majoring in electrical engineering at WPI and earning a master’s at MIT. It took a decade in the computer chip industry for him to “go back to first principles,” as he puts it, and face his mother’s vision of what he was born to do. “I kept asking myself, ‘Why aren’t you a physician?’” he says. There came a time when the only way he could respond to that question was to become one.
The engineer did not get left behind. At Stanford Medical School in the early 1990s, he found an educational system that was opening up to engineering-style thinking. “Before that time, medical school was about memorizing everything you can and doing table look-up,” he says. While many of his med school classmates had spent their college years cramming for exams, Hoyte’s undergraduate work, in the early years of the WPI Plan, had trained him to analyze problems and seek solutions. “The Plan was one of the best things that happened to me.”
Today Hoyte is innovating with an engineer’s mind and doing the hands-on healing his mother envisioned. At the Pelvic Floor Institute (which he founded in 2016, with offices in Tampa and Sarasota, Fla.), he treats women who suffer from disorders that are common consequences of bearing children—and of getting older. In his research, he is developing predictive models, informed by high-tech imaging and big data algorithms, that can help women make informed choices about their medical care.
“With my background, I was a natural for the OB/GYN specialty,” he says. Though he enjoyed delivering babies, he became intrigued by the biomechanics of the female pelvic floor: what can go wrong, and how to fix it. It was here that the midwife’s son, the engineer, and the urogynecologist found their true work.
To understand how the bones and muscles of the female pelvic basin work together to support internal organs, one must fully comprehend their complex anatomy—in three dimensions. Starting in his residency at Brigham and Women’s Hospital, Hoyte began using magnetic resonance imaging (MRI) to create 3-D reconstructions of normal and dysfunctional anatomy. Since then, he’s created atlases and tutorials that demonstrate aberrations in full color, one structure at a time.
An Ancient Art, a Young Specialty
Hoyte sums up his specialty, female pelvic medicine and reconstructive surgery (FPMRS), with frank humor: “If it’s falling out, leaking, or hurting—between the belly button and upper thighs—and the patient is female, that’s what I take care of.” It’s estimated that a third of women who have given birth vaginally, and half of women over the age of 50, experience some symptoms of pelvic floor prolapse (often described as organs “falling” out of position). Eve could have been his first patient—but Hoyte is a pioneer in a clinical discipline that, as a formal subspecialty, is only about five years old. He’s done much to further training in the field, including launching and directing the first clinical fellowship program in FPMRS in the state of Florida (at the University of South Florida College of Medicine). “If you have an F-15 aircraft, you don’t go to a bicycle mechanic to fix it,” he says. “I designed our FPMRS program to create thoughtful, analytic, highly competent, and sought-after subspecialists in our field.”
Over the last few decades, Hoyte has seen greater openness about female pelvic floor disorders, thanks in part to public information efforts of the National Institutes of Health and patient advocacy groups. Yet he still sees patients who come in seeking help for incontinence, prolapse, or sexual dysfunction, thinking they suffer alone. “They’re relived when I tell them their condition is common—and often fixable,” he says. He helps them consider options—which can include observation, physical therapy, or minimally invasive surgical reconstruction.
“Surgery is pretty much an ancient art,” says Hoyte. Early in his practice, he observed that the techniques being used for pelvic floor reconstruction “hadn’t really evolved.” While minimally invasive approaches, such as laparoscopy, offered some advantages, he says, “I looked at it with my engineering background and saw that the laparoscope was just not set up to work optimally in the confined space of the pelvic cavity.” He was an early adopter of the robotic-assisted da Vinci Surgical System and has developed specialized techniques and tools that make complex surgical procedures simpler,faster, and safer.
For Hoyte, “personalized patient care” means more than just an attentive bedside manner. He wants to know how a particular patient’s pelvic muscles and ligaments will withstand the stresses of childbirth. He also wants to assess which of the various repair options would give the best outcome for each patient. Under his guidance, researchers in his group have identified critical markers—such as muscle shape and thickness, and bony geometry—that go beyond what a doctor can learn in a physical exam. “By taking a few selected measurements,” says Hoyte, “we can tell a patient what the success rate of prolapse repair will be, using a particular surgical approach.”
Perhaps his most exciting research is in developing 3-D computer simulations of childbirth. “We can pass a model fetal head through the pelvis and look at the damage that occurs—on the computer,” he says. With enough data, Hoyte sees a future in which “we’ll be able to look at a particular patient, get an MRI scan, perhaps do a blood test to assess her biomechanical tissue properties, and run computer simulations of different birth scenarios.” With the right algorithms, he says, “We could tell that woman, based on her baby’s weight and head size, and how long labor lasts, what her risk of childbirth injury would be with vaginal delivery.” He stresses that the goal of his research is to be able to present options, so the patient and doctor can make informed decisions together.
“We build cars and test aircraft on a computer before we build the physical model,” proclaims Hoyte. “Why are we repairing pelvic floors without running computer-based simulations of the different repair options, so we can figure out which one is right for you? Your pelvic floor is worth more than that!”
The Right Tools
Back when he worked in the computer industry, Hoyte’s tools included CAD programs that were developed by the people who actually used them. “The tool builders were the tool users,” he points out. “So the tools were optimized for them.” Today he wants to bring that same ethic to the programs used for computerized medical records. He laments that the shift to electronic records has caused doctors to shift their focus from talking with patients to entering data. “How do we optimize the building of a medical record so that the doc can be back in charge of how it functions?” he asks, “and so that the doctor–patient relationship comes first?”
The Pelvic Floor Institute is a “testbed” for the HIPAA-compliant electronic medical records software that Hoyte is designing with colleagues. To head up that R&D, he recruited another WPI-trained engineer: his son, Dante Johnson-Hoyte ’13, who serves as the Institute’s chief technology officer. Dante is continuing the family legacy of keeping patient care personal.
“My mom was an amazing care provider,” says Hoyte. “My goal in my practice was to build a personalized model of pelvic floor care, where the ‘engineer’—that is, the doctor—listened carefully to the patient to help define what her individual problem is—and then set about solving that problem.” It’s an approach he says harks back to the competency exams that WPI students took in the 1970s.
“My WPI experience taught me to think about every single patient as a specific engineering challenge—where I have to learn what the question is by listening to the patient; to use my scientific understanding to develop and test hypotheses regarding her care options; and to deliver a personalized solution for that patient.”
It’s a vision that would make his late mother proud.
First published in WPI Journal, Summer 2017 edition