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SEQUENCE:1
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UID:109981
DTSTAMP:20231204T110841Z
DTSTART;TZID=America/New_York:20231211T120000
DTEND;TZID=America/New_York:20231211T125000
URL;TYPE=URI:https://www.wpi.edu/news/calendar/events/bme-seminar-series-an
 dre-issacs-phd-college-holy-cross-click-chemistry-approach-nitrogen
SUMMARY:BME Seminar Series: Andre Issacs\, PhD\, College of the Holy Cross:
  A Click Chemistry Approach to Nitrogen Heterocycles
DESCRIPTION:A Click Chemistry Approach to Nitrogen Heterocycles\n\n\n\n    
   \n      \n\n\n\nAndré K. Issacs\, PhDAssociate Professor ofChemistry\, 
 College of the Holy Cross\nMonday\, December 11\, 2023\nGateway 1002\n12:0
 0pm – 12:50pm\nAbstract: My research interest is centered on a very reli
 able organic reaction - the copper-catalyzed cycloaddition of sulfonyl azi
 des and terminal alkynes (CuAAC). Differential fragmentation of the result
 ing 1\,2\,3-triazole generates ketenimines or rhodium carbenoids which rea
 dily engage with a variety of nucleophiles to provide access to heterocycl
 es of interest to the synthetic community. We’ve demonstrated the utilit
 y of click chemistry in the synthesis of N-Heterocycles such as indolizine
 s\, dihydroisoquinolines and as an approach to beta-lactams.\nBiography: A
  native of Jamaica\, André moved to the US to attend the College of the H
 oly Cross where he received his B.A. in Chemistry in 2005. As an undergrad
 uate\, he conducted research in the labs of Kevin J. Quinn focusing on the
  total synthesis of annonaceous acetogenins Muricatacin and Rollicosin. He
  received his PhD from the University of Pennsylvania in 2011 (under the g
 uidance of Professor Jeffery D. Winkler)\, where he focused on the design 
 and synthesis of novel steroid-derived inhibitors of Hedgehog-signaling\, 
 based on the alkaloid cyclopamine. He worked as a post-doctoral researcher
  with Professor Richmond Sarpong at the University of California\, Berkele
 y\, where he focused on the synthesis of diterpenoids and the radiolabeled
  insecticide chlorantraniliprole. In 2012\, Andre accepted a tenure-track 
 position at the College of the Holy Cross. In 2018\, Andre was promoted to
  the rank of Associate Professor with tenure. In addition to teaching cour
 ses in Organic Chemistry\, Andre conducts research utilizing copper-mediat
 ed organic transformations. He is one of the co-founding members of Outfro
 nt - the college’s LGBTQ faculty and staff alliance and serves as facult
 y advisor to several student groups including the Caribbean African Studen
 ts’ Assemblage\, acapella group Fools on the Hill and Club Tennis.
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