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URL;TYPE=URI:https://www.wpi.edu/news/calendar/events/bme-ms-project-presen
 tation-anna-callaghan-effects-surface-topography-and-attachment-factor
SUMMARY:BME MS Project Presentation: Anna Callaghan “The Effects of Surface
  Topography and Attachment Factor Solutions on Endothelial Cell Morphology
  Under Laminar and Disturbed Flow Conditions”
DESCRIPTION:\n\n\n      \n      \n\n\n\nMaster’s Project Presentation\n\n“T
 he Effects of Surface Topography and Attachment Factor Solutions on Endoth
 elial Cell Morphology Under Laminar and Disturbed Flow Conditions”\nAnna C
 allaghan\nAbstract: Cardiovascular disease remains a leading cause of mort
 ality worldwide, with 20.5 million deaths reported in 2021. The current go
 ld standard treatments are bare metal and drug eluting stents, which are a
 ssociated with inflammation, thrombosis, mechanical damage to the vessel w
 all, and Intimal Hyperplasia (IH). However, bioresorbable stents fabricate
 d via micro-continuous liquid interface production (microCLIP) have emerge
 d. This promising technique could allow personalized medical care. However
 , there is a gap in understanding how surface topography and various cell 
 attachment solutions influence endothelial cells (ECs) under hemodynamic c
 onditions. Micropatterned scaffolds and various attachment factor solution
 s were used to model cell morphology and retention rate under laminar and 
 disturbed flow. This study evaluated the morphological responses of human 
 aortic ECs (HAECs) and human umbilical vein ECs (HUVECs) seeded on nanopor
 ous patterned and flat scaffolds coated with either a fibronectin and coll
 agen solution or an extracellular matrix attachment factor solution (EMAF)
  under laminar flow, disturbed flow, and static control conditions. Sample
 s were imaged using spinning disk confocal microscopy and analyzed in Imag
 eJ FIJI. Statistical comparisons were performed using Kruskal-Wallis tests
  with Dunn's post-hoc correction. In both coating conditions and under bot
 h flow conditions, results demonstrated that substrates with topography si
 gnificantly promoted cell elongation and alignment more than flat substrat
 es. This data supports the idea that surface topography and various coatin
 gs should be incorporated into future bioresorbable stents to promote endo
 thelial health.\n\n\n\n\nProject Advisor:\nDefense Committee:\n\n\n\n\nYon
 ghui Ding, PhD\nAssistant Professor\nBiomedical Engineering\nWorcester Pol
 ytechnic Institute\n\n\nSolomon Mensah, PhD (Chair)\nAssistant Professor\n
 Biomedical Engineering\nWorcester Polytechnic Institute\n\n\nZhenglun Alan
  Wei, PhD\nAssistant Professor\nBiomedical Engineering\nWorcester Polytech
 nic Institute\n\n\n\n\nFor a zoom link, please email kharrison@wpi.edu  \n
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