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URL;TYPE=URI:https://www.wpi.edu/news/calendar/events/mathematical-sciences
 -department-colloquium-rayanne-luke-george-mason-university-sh-202
SUMMARY:Mathematical Sciences Department Colloquium - Rayanne A. Luke, Geor
 ge Mason University (SH 202)
DESCRIPTION:\n\n\n      \n      \n\n\n\nMathematical Sciences Department Co
 lloquium\nFriday, August 21\n11:00 AM - 12:00 PM\nStratton Hall 202\nRayan
 ne A. Luke, Department of Mathematical Sciences, George Mason University\n
 Title: Mathematical Models of Contact Lens Drug Delivery: Blinking and Len
 s Design\nAbstract: Drug-eluting contact lenses are an ophthalmic drug del
 ivery alternative to eye drops. Such lenses can significantly increase dru
 g residence time and therefore effectiveness. We design models of contact 
 lens drug delivery to align with experimental systems and consider blinkin
 g and lens design. Our approach couples partial differential equations for
  linear diffusion of drug inside the contact lens with compartment models 
 for the pre- and post-lens tear films and the eyelid region. To study blin
 king, we model the effect of a blink on the pre- and post-lens tear film d
 rug concentrations, investigating mechanisms such as partial or full sweep
  out of drug by the eyelid, and squeezing or sliding of the lens. The most
  likely scenario is identified by comparing to model eye data. To study le
 ns design, we model drug-polymer films encapsulated in hydrogel lenses, wh
 ere the drug-laden region appears as an annulus in a top-down view. We inv
 estigate the dependence of drug release time on lens material and geometri
 c properties and identify drug delivery transport mechanisms by comparing 
 to in vivo data. In both cases, we recover drug cumulative release profile
 s from experimental systems, and determine the effects of blinking and len
 s design properties on cumulative release. This can inform our understandi
 ng of the mechanics of contact lens drug delivery and predict targeted tis
 sue transport of drug.\n
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