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DTSTART:20070311T020000
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UID:250316
DTSTAMP:20261030T105250Z
DTSTART;TZID=America/New_York:20261106T110000
DTEND;TZID=America/New_York:20261106T120000
URL;TYPE=URI:https://www.wpi.edu/news/calendar/events/mathematical-sciences
 -department-colloquium-yuehui-xu-wpi
SUMMARY:Mathematical Sciences Department Colloquium: Yuehui Xu\, WPI
DESCRIPTION:Speaker: Yuehui Xu\, WPI\nTitle: A geometry-dependent\, force-b
 alance driven model of biofilm cell cluster detachment\nAbstract: Biofilms
  are bacterial communities embedded in extracellular polymeric substance (
 EPS) matrices that form on medical devices and industrial surfaces. We pre
 sent a multiscale modeling framework that predicts biofilm detachment by c
 oupling stochastic agent-based microstructure to cluster-level mechanics. 
 Using iDynoMiCS simulation\, we generate realistic biofilms and identify c
 andidate detachment clusters based on local EPS disruption and spatial den
 sity. Detachment is decided by a geometry-dependent moment balance: cluste
 rs detach when hydrodynamic drag moment exceeds adhesive moment. Our resul
 ts show that EPS disruption accelerates removal\, larger clusters are more
  elongated\, and initial biofilm structure influences detachment statistic
 s. The model predicts distributions of detached cluster size and shape\, p
 roviding a reusable framework for understanding biofilm control across spe
 cies and conditions.
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