Email
jmcoburn@wpi.edu
Office
Gateway 4012
Interdisciplinary Groups

BioPoint

Biosciences and Biomanufacturing

Affiliated Department or Office
Education
BS Chemical Engineering University of Massachusetts – Amherst 2006
PhD Chemical and Biomolecular Engineering Engineering, Johns Hopkins University, 2012
Postdoc Biomedical Engineering Tufts University 2012-2016

The overall objectives of my research are to develop clinically translatable tissue regeneration and drug delivery strategies, and three-dimensional, in vitro human disease models using biologically-derived biomaterials. We will utilize techniques from engineering, chemistry and biology to address these research areas, including chemical modifications to alter drug-material interactions, small molecule and macromolecule conjugates to direct cell fate, and multi-cellular tissue/disease systems for paracrine signaling and direct cell-cell interactions. My research is focused on biomaterials and their applications in tissue engineering and drug delivery. During my PhD, I worked with photo-crosslinked PEGDA hydrogel systems to study repair strategies for articular cartilage diseases. I also developed low density, bioactive-electrospun fiber scaffolds for repair of articular cartilage defects. My postdoctoral research used silk fibroin proteins from Bombyx mori silkworm cocoons for (1) drug delivery systems for oncology therapeutics and HIV treatment/prevention and (2) tissue regeneration of the kidney and pancreas. In the lab and the classroom, I truly enjoy teaching. I am especially excited to mentor students on their Major Qualifying Projects. I strive to ensure that students are able to (1) apply theoretical concepts to practical applications and (2) fully understand the tasks being performed.

Email
jmcoburn@wpi.edu
Office
Gateway 4012
Owner
Interdisciplinary Groups

BioPoint

Biosciences and Biomanufacturing

Scholarly Work

Ornell KJ, Taylor JS, Zeki J, Ikegaki N, Shimada H, Coburn JM, Chiu B. (2020) Local delivery of Dinutuximab from silk protein biomaterial for treatment of orthotopic neuroblastoma model.
Montoya NV, Peterson R, Ornell KJ, Albrecht DR, Coburn JM. (2020) Silk particle production based on silk/PVA phase separation using a microfabricated co-flow device. MDPI Molecules. 25(4): 890.
Ornell KJ, Chiu, B, Coburn JM. (2020) Development of a dinutuximab delivery system using silk foams for GD2 targeted neuroblastoma cell death. Journal of Biomedical Research Part A. 109(8):1393-1405.
Carnes ME, Gonyea CR, Mooney RG, Njihia JW, Coburn JM, Pins GD. (2020) Horseradish peroxidase-catalyzed crosslinking of fibrin microthread scaffolds. Tissue Engineer Part C. 26(6):317-331.
Phan NV, Wright T, Xu J, Coburn JM. (2020) In vitro biocompatibility of decellularized cultured plant cell-derived matrices. ACS Biomaterials Science and Engineering. 6(2): 822-832.
Gupta AK, Sarkar P, Coburn JM, Davis-Knowlton J, Palma EK, Kaplan DL, Oxburgh L. (2019) Scaffolding kidney organoids on silk. Journal of Tissue Engineering and Regenerative. 108(8):2748-2755.
Professional Highlights & Honors
2021 Trustee Award for Outstanding Academic Advising
2020 WPI Sigma Xi Outstanding Junior Faculty Award
2020 Biomaterials Science Emerging Investigators, Royal Society of Chemistry
2019 - 2020 WPI BME Teacher of the Year Award
Title
Ruth L. Kirschtein NIH/NIDDK Postdoctoral Fellowship (2013-2016)
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Ruth L. Kirschtein NIH/NIA Predoctoral Fellowship (2010-2012)