Although the biomechanical mechanisms of traumatic brain injury have been investigated for more than half a century, an effective criterion for injury assessment has yet to be established. An important reason is that how the impact energy transforms into brain tissue deformation is still unclear. Impact kinematics have long been used to predict injury as they can be directly measured, recorded, or reconstructed from real-world head impacts. However, they do not directly inform the mechanical responses of the brain. Therefore, an important goal of my research is to develop a head injury model, which is computationally efficient but biomechanically sophisticated. The model will serve as a significant bridge to connect impact kinematics to the mechanical responses of the brain. Ultimately, the model will allow researchers to estimate real-time mechanical responses of the brain accurately.