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Contact Information

Office:
Life Sciences & Bioengineering Center, 3005
Phone: +1-508-831-4193
Fax: +1-508-831-4116
rdempski@wpi.edu

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Robert E. Dempski

Our research focus is to combine biochemical and biophysical techniques to investigate the structure and function of two classes of membrane proteins. In the first instance, we are investigating the mechanism of a zinc transporter, hZIP4. This protein has been implicated in the initiation and progression of pancreatic cancer. Despite the central role of this protein in cellular homeostasis, the mechanism of cation transport is not well understood. Secondly, we have been investigating the molecular determinants that help to define the functionality of opsin proteins.

Research Interests

  • Biophysics
  • Membrane biology
  • Membrane proteins

Education

  • BS, Bucknell University, 1997
  • PhD, Massachusetts Institute of Technology, 2003 

Featured Publications

  • Richards, R., and Dempski, R.E. “Examining the Conformational Dynamics of Membrane Proteins in Situ With Site-Directed Fluorescence Labeling,” Journal of Visualized Experiments (2011).
  • Kleinlogel, S., Feldbauer, K., Dempski, R.E., Fotis, H., Wood, P.G., Bamann, C., and Bamberg, E. “Ultra Light-Sensitive and Fast Neuronal Activation with the Ca++ Permeable Channelrhodopsin, Catch,” Nature Neuroscience, 14, 513-5518 (2011).
  • Geys, S., Bamberg, E., and Dempski, R.E. “The Conformational Dynamics of the M3-M4 Loop of the Na+/K+-Atpase Are Influenced by Cation Concentration,” Biophysical Journal, 96, 4561-4570 (2009).
  • Dempski, R.E., Friedrich, T., and Bamberg. “E.Voltage Clamp Fluorometry: Combining Fluorescence and Electrophysiological Methods to Examine the Structure-Function of the Na(+)/K(+)-Atpase,” Biochimica et Biophysica Acta, 1787, 714-720 (2009).
  • Dempski, R.E., Lustig, J., Friedrich, T., and Bamberg, E. “Structural Arrangement and Conformational Dynamics of the Gamma Subunit of the Na+/K+-Atpase,” Biochemistry, 47, 257-266 (2008).
 
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