Project Type MQP Submission date 2007-03-02 Authors Melissa A. Byrne, BE Benjamin C. Cleveland, BE Joseph E. Marturano, BE URN E-project-030207-112622 Title Design of a reproducible murine fracture device Advisor Billiar, Kristen, BE Availability unrestricted
Mouse models are commonly used to investigate bone healing and test new treatments. The objectives of this project were to design a fracture device to create a reproducible transverse fracture in the mouse femur and to establish the limits of achieving transverse fractures. Testing with 26.4 +/- 6.1g wildtype mice (n=120) developed a model equation of mv^2=0.292 to predict a 95% transverse fracture success rate. These results are useful to researchers who are interested in obtaining a higher transverse fracture success rate.
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