Title page for E-project-042506-120742

Project Type	MQP
Submission date	2006-04-25
Authors	Ashley J Bourgault, CM Matthew J Regan, CM
URN	E-project-042506-120742
Center	Nancy, France
Sponsor	ENSIC
Title	Modified Dextran Polymers for Drug Delivery
Advisors	Camesano, Terri Anne, CM McGimpsey, W. Grant, CH
Availability	unrestricted
Abstract A collaboration between WPI and ENSIC was undertaken to investigate the properties of emulsions as a drug delivery system. Biocompatible amphiphilic polymers are used as emulsifiers for controlled drug delivery. They act as a barrier between phases in oil-in-water emulsions to increase stability. Oil soluble drugs can be encapsulated within the oil nanoparticles and released into a biological system. The goal of this project was to study modified dextran (DexC6), an amphiphilic polymer. The most stable emulsions were formed with a DexC6 aqueous concentration of 40g/L in a system of 40% octyldodecanol oil volume. Drug release kinetic experiments showed that encapsulated lidocaine is released at a slower rate than free lidocaine. Further research in emulsion drug delivery is recommended.
Files	Drug_Delivery_Final_MQP_2006.pdf Final_Drug_Delivery_Poster_2006.ppt

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