Worcester Polytechnic Institute Electronic Theses and Dissertations Collection

Title page for ETD etd-020413-153839

Document Typethesis
Author NameWang, Yao
TitleStructural and Functional Connectivity Analyses of Rat Brains Based on fMRI Experiments
DepartmentMechanical Engineering
  • John M. Sullivan, Jr., Advisor
  • Keywords
  • fMRI
  • rat atlas
  • functional connectivity
  • Date of Presentation/Defense2012-11-07
    Availability unrestricted


    Various topics on functional magnetic resonance imaging (fMRI) analyses have been in study through the last 30 years. This work delineates the pathways required for resting-state functional connectivity analyses, which illuminates the correlations between different rat brain regions and can be presented in a functional connectivity matrix. The matrix is built based on the category nomenclature system of Swanson Rat Atlas 1998. From which a structural connectivity matrix is also built. This work developed the complete functional connectivity counterpart to the physical connections and explored the relationships between the functional and structural connectivity matrices. The functional connectivity matrices developed in this work map the entire rat brain. The results demonstrate that where structural connectivities exist, functional connectivities exist as well. The methodologies used to create the functional and structural analyses were completely independent.

  • YWang.pdf

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