Title page for ETD etd-0830100-001359

Document Type dissertation

Author Name Parikh, Bhairavi Rajiv

Email Address brparikh at yahoo.com

URN etd-0830100-001359

Title The design and development of a direct and continuous sensor for the measurement of inhaled nitric oxide concentrations

Degree PhD

Department Biomedical Engineering

Advisors
Dr. Robert A. Peura, Advisor
Dr. Babs R. Soller, Advisor
Dr. Christopher Sotak, Department Head
Dr. Stevan Kun, Committee Member

Keywords
inhaled
nitric oxide
optical
sensor

Date of Presentation/Defense 2000-06-12

Availability unrestricted

Abstract
Gaseous nitric oxide, in concentrations between 0 and 20 ppm, is currently being used to treat patients with post-surgical complications and respiratory disorders. Currently available instruments are expensive and have problems that limit their usefulness for this application. This thesis discusses the development of an inexpensive, direct and continuous sensor for the measurement of inhaled nitric oxide.

The prototype sensor incorporates a 0.125 cm, gas permeable, flow-thru liquid cell into a probe that can be incorporated into a ventilator circuit. Sensor operation is based on the complexation reaction of NO with cytochrome-c (Fe III), a biologically derived heme. The complex is monitored spectrophotometrically in the visible region of the spectrum at 563 nm by an optical spectrograph card. LabVIEW is used for all hardware control, signal acquisition, data processing, display and storage. The sensor has a sensitivity of 2x10-4 Abs/ppm, where Abs denotes absorbance units, a minimum detectable limit of 1.5 ppm, resolution of 0.5 ppm, is stable over the course of 8 hours, has less than 1 ppm error and a response time of less than 2 minutes. All aspects of sensor design and development will be discussed.

Files
parikh.pdf

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Document Type	dissertation
Author Name	Parikh, Bhairavi Rajiv
Email Address	brparikh at yahoo.com
URN	etd-0830100-001359
Title	The design and development of a direct and continuous sensor for the measurement of inhaled nitric oxide concentrations
Degree	PhD
Department	Biomedical Engineering
Advisors	Dr. Robert A. Peura, Advisor Dr. Babs R. Soller, Advisor Dr. Christopher Sotak, Department Head Dr. Stevan Kun, Committee Member
Keywords	inhaled nitric oxide optical sensor
Date of Presentation/Defense	2000-06-12
Availability	unrestricted
Abstract Gaseous nitric oxide, in concentrations between 0 and 20 ppm, is currently being used to treat patients with post-surgical complications and respiratory disorders. Currently available instruments are expensive and have problems that limit their usefulness for this application. This thesis discusses the development of an inexpensive, direct and continuous sensor for the measurement of inhaled nitric oxide. The prototype sensor incorporates a 0.125 cm, gas permeable, flow-thru liquid cell into a probe that can be incorporated into a ventilator circuit. Sensor operation is based on the complexation reaction of NO with cytochrome-c (Fe III), a biologically derived heme. The complex is monitored spectrophotometrically in the visible region of the spectrum at 563 nm by an optical spectrograph card. LabVIEW is used for all hardware control, signal acquisition, data processing, display and storage. The sensor has a sensitivity of 2x10-4 Abs/ppm, where Abs denotes absorbance units, a minimum detectable limit of 1.5 ppm, resolution of 0.5 ppm, is stable over the course of 8 hours, has less than 1 ppm error and a response time of less than 2 minutes. All aspects of sensor design and development will be discussed.
Files	parikh.pdf