Email
sshell@wpi.edu
Office
Life Sciences & Bioengineering Center 4016
Phone
+1 (508) 8315000 x5917
Personal Website
Lab Links
Shell Lab
Affiliated Department or Office
Bioinformatics & Computational Biology
Education
BA Smith College 2001
PhD University of California, San Diego 2008

I have a passion for understanding how living systems work, as well as for sharing my love of biology and research with the next generation of scientists and informed citizens.

The central goal of my lab is to understand the regulatory mechanisms that underlie mycobacterial stress tolerance. We combine genetics, genomics, transcriptomics and biochemistry to understand how mycobacteria respond to, and ultimately survive, stressful conditions.

Our guiding principles are curiosity, respect, and scientific rigor. Together we strive to push the boundaries of knowledge and advance our field by addressing basic research questions that hold the keys to advancements in human health and understanding of the natural world.

To treat many infectious diseases, including the global scourge of tuberculosis, doctors must do battle with a wily adversary, bacteria. Unfortunately for afflicted patients, bacteria have also acquired strategies for thwarting attacks from the immune system and the onslaught of antibiotic drugs. We need to know more about the strategies bacteria use to survive stresses. Biology and biotechnology professor, Scarlet Shell, is seeking to do just that by probing the molecular changes that underlie these mechanisms.

Research Interests
Bacterial Stress Response
Bacterial Pathogenesis
Regulation of Gene Expression
Epigenetics
Genomics and Transcriptomics

Scholarly Work

Vargas-Blanco, D.A., Zhou, Y., Zamalloa, L.G., Antonelli, T., and Shell, S.S. (2019). mRNA Degradation Rates Are Coupled to Metabolic Status in Mycobacterium smegmatis. mBio, DOI: 10.1128/mBio.00957-19.
2019

Vargas-Blanco, D.A., and Shell, S.S. (2020). Regulation of mRNA Stability During Bacterial Stress Responses. Frontiers in Microbiology. 11:2111. doi: 10.3389/fmicb.2020.02111.
2020

Martini, C.M., Zhou, Y., Sun, H., and Shell, S. S. 2019. Defining the Transcriptional and Post-transcriptional Landscapes of Mycobacterium smegmatis in Aerobic Growth and Hypoxia. Frontiers in Microbiology, 10: 591. doi:10.3389/fmicb.2019.00591 2019

Datta, P., Ravi, J., Guerrini, V., Chauhan, R., Neiditch, M.B., Shell, S.S., Fortune, S.M., Hancioglu, B., Igoshin, O., Gennaro, M. L. 2015. The Psp system of Mycobacterium tuberculosis integrates envelope stress sensing and envelope preserving functions. Molecular Microbiology. doi:10.1111/mmi.1303

Shell, S. S., Chase, M. R., Ioerger, T. R., & Fortune, S. M. 2015. RNA sequencing for transcript 5'-end mapping in mycobacteria. Methods in Molecular Biology (Clifton, N.J.), 1285, 31–45. doi:10.1007/978-1-4939-2450-9_3.

Shell, S.S., Prestwich, E.G., Baek, S.H., Shah, R.R., Sassetti, C.M., Dedon, P.C., and Fortune, S.M. 2013. DNA Methylation Impacts Gene Expression and Ensures Hypoxic Survival of Mycobacterium tuberculosis. PLoS Pathogens. 9(7): e1003419. doi:10.1371/journal.ppat.1003419

Professional Highlights & Honors
Board of Trustees Award for Outstanding Advising, 2019
WPI
Sigma Xi Award for Outstanding Research and Scholarship, 2020
WPI

News

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Media Coverage

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Telegram.com
WPI Professor Receives $1.1 Million Grant for Bacteria Study

Scarlet Shell, assistant professor of biology and biotechnology, has received a $1.1 million CAREER Award from the National Science Foundation for a five-year program to study the molecular mechanisms bacteria use to survive stressful conditions of starvation and lack of oxygen.