Professor Guler's research interests lie in the broad area of circuits and systems, with a primary area of interest in analog/mixed-signal integrated circuits. More specifically, she is interested in the circuit design of sensing interfaces and energy harvesting and wireless power transmission systems for applications in the IoT.

Guler does research on wearable technologies. She studies the use of wearables for noninvasive monitoring of vital signs related to oxygenation and ventilation, for at-home use. Her research seeks to develop wearable sensors to accurately measure oxygen levels in premature infants, potentially allowing for earlier discharge from the hospital; as well as in COPD patients and the elderly, potentially allowing for a higher quality of life. She can speak about the potential for noninvasive monitoring of blood oxygen and carbon dioxide partial pressures; and the challenges and opportunities associated with designing wearables to monitor physiological parameters.