EPICC Published Pain Research

Endometriosis pain

Wayne P.M., Kerr .CE., Schnyer R.N., Legedza A., Savetsky German J., Shields M.H., Davis R.B. Buring,  Conboy L.A., Highfield E, Parton B, Thomas P, Laufer MR. (2008). Japanese-Style Acupuncture for Endometriosis-Related Pelvic Pain in Adolescents and Young Women: Results of a Randomized Sham-Controlled Trial. Journal of Pediatric and Adolescent Gynecology. 21(5):247-57. PMID: 18794019. 

Conboy L.A., Quilty M., Kerr C., Shaw J., Wayne P. (2008). A qualitative analysis of adolescents’ experiences of active and sham Japanese-style acupuncture protocols administered in a clinical trial. Journal of Alternative and Complementary Medicine. 14(6):699-705. PMID: 18684076.

Ahn A.C., Schnyer R, Conboy L.A., Wayne P.M. (2009). Electrodermal Measures of Jing-Well Points and their Clinical Relevance in Endometriosis-Related Chronic Pelvic Pain. Journal of Alternative and Complementary Medicine. J Altern Complement Med. 15(12):1293-305.PMID: 19958132


Placebo effect in pain conditions

Stone D.A., Kerr C.E., Conboy L.A., Jacobson E, Kaptchuk T.J.(2005). Patient expectations in placebo-controlled randomized trials. J Evaluation Clin Pract. 11(1): 77-84.PMID: 15660541.

Patel S.M., Stason W.B., Legedza A, Ock S.M., Kaptchuk T.J., Conboy L.A., Canenguez K, Park J.K., Kelly E., Jacobson E, Kerr C.E., Lembo A.J. (2005). The placebo effect in Irritable Bowel Syndrome Trials: a Meta-analysis. Neurogastroenterol Motil. 17:332-340.. PMID: 15916620.

Conboy, L.A., Wasserman R.H., Legedza A.T., Park M., Rivers A., Morey E.B., Nam B.H., Jacobson E.E., Lembo A.J., Kaptchuk T.J., Kerr C.E. (2006). Investigating Placebo Effects in Irritable Bowel Syndrome: A Novel Research Design. Journal of Controlled Clinical Trials. 27(2):123-34. PMID: 16427366.

Dorn S.D., Kaptchuk T.J., Park J., Canenguez K., Nam B.Y., Long N., Woods K.B., Conboy L.A., Stason W.B., Lembo A.J. (2007). A meta-analysis of the placebo response in complementary and alternative medicine trials or irritable bowel syndrome. Neurogastroenterology and Motility. 19(8): 160-7. PMID: 17640177.

Kaptchuk T.J., Kelley J.M., Conboy L.A., Davis R.B., Kerr C.E., Jacobson E.E., Kirsch I, Schyner R.N., Nam B.Y., Nguyen L.T, Park M, Rivers A.L., McManus C., Kokkotou E., Drossman D.A., Goldman P., Lembo A.J. (2008). Components of the Placebo Effect: A randomized controlled trial in irritable bowel syndrome. BMJ.336:998-1003.PMID: 18390493.

Kelley J.M., Lembo A.J., Ablon J.S., Villanueva J.J., Conboy L.A., Levy R, Marci C.D., Kerr C.E., Kirsch I, Jacobson E.E., Riess H, Kaptchuk T.J. (2009). Patient and practitioner influences on the placebo effect in irritable bowel syndrome. Psychosomatic Medicine.71 (7):789-97. PMID: 19661195

Kaptchuk T.J., Shaw J, Conboy L.A., Kerr C.E., Jacobson E.E. (2009). Maybe I Made Up the Whole Thing: Placebos and Patient’s Experiences in Randomized Controlled Trials. Culture, Medicine, and Psychiatry. 33(3):382-411.PMID: 19597976.


Irritable Bowel Syndrome

Feman S.P., Nguyen L.T., Quilty M.T., Kerr C.E., Nam B.H., Conboy L.A., Singer J.P., Park M., Lembo A., Kaptchuk T.J., Davis R.B. (2007). Effectiveness of Recruitment in Clinical Trials: An Analysis of Methods Used in a Trial for Irritable Bowel Syndrome Patients. Contemporary Clinical Trials. Sept 7. PMID: 17919993.

Conboy L.A., Macklin E, Kelly J, Kottotou E, Lembo A, Davis R, Kaptchuk T.J. (2009). Which patients improve: characteristics increasing sensitivity to a supportive patient-practitioner relationship. Social Science and Medicine. 70(3):479-84. PMID: 19900742

Lembo A., Conboy L.A., Schnyer R.N., Kelley J.M. (2009). A Treatment Trial of Acupuncture in IBS Patients. The American Journal of Gastroenterology. 104(6):1489-97.PMID: 19455132.

Passos M.C.F., Lembo A.J., Conboy L.A., Kaptchuk T.J., Kelley J.M., Quilty M.T., Kerr C.E., Jacobson E.E., Hu R, Friedlander E, Drossman D. (2009). Adequate relief in a treatment trial with IBS patients: a prospective assessment. Amer J Gastroenterology. 104(4):912-9.PMID: 19293784.

Kokkotou E, Conboy L.A., Ziogas D.C, Quilty M.T, Kelley J.M, Davis R.B, Lembo A.J, Kaptchuk T.J.(2009). Serum correlates of the placebo effect in irritable bowel syndrome. Neurogastroenterol Motil. Epub ahead of print. PMID: 20028464.

Cremonini F, Ziogas D.C., Chang H.Y., Kokkotou E, Kelley J.M., Conboy L.A., Kaptchuk T.J., Lembo A.J.(2010). Meta-analysis: the effects of placebo treatment on gastro-oesophageal reflux disease. Aliment Pharmacol Ther. 2010 Jul;32(1):29-42. Epub.PMID: 20353496.

Hall K, Lembo A, Kirsch I, Ziogas D, Douaiher J, Jensen K, Conboy L.A., Kelley J, Kokkotou E and Kaptchuk T, (2012) Catechol-O-methyltransferase val158met Polymorphism Predicts Placebo Effect in Irritable Bowel Syndrome. PLoS One. 2012;7(10):e48135. PMID:23110189.

Hall K.T., Tolkin B.R., Chinn G.M., Kirsch I, Kelley J.M., Lembo A.J., Kaptchuk T.J., Kokkotou E, Davis R.B.,   Conboy L.A.(2015) Conscientiousness is modified by genetic variation in catechol-O-methyltransferase to reduce symptom complaints in IBS patients. Brain Behav.Jan;5(1):39-44.


Pain in Palliative Care population

Romeo M, Parton B, Russo R, Hayes L, Conboy L.A. (2015). Acupuncture to Treat the Symptoms of Patients in a Palliative Care Setting.  Explore. Jul 2. pii: S1550-8307(15)00108-1. doi: 10.1016/j.explore.2015.06.001. PMID:26254221.


Musculoskeletal Pain

Hsu KY, Conboy L.A.(2014).Who might benefit from acupuncture for musculoskeletal pain: results from a student clinic. J Altern Complement Med.20(5):A41-2. PMID:24805600.

Hsu KY, Chui KK, Conboy L. Are Baseline Characteristics Related to Responses to Acupuncture Treatment for Musculoskeletal Conditions? Analysis of a Dataset from a Teaching Centre. Acupunct Med. 2016 Oct; 34(5):408-409. PMID: 27390255.


Gulf War Illness

Conboy L.A., St John M, Schnyer R.(2012). The effectiveness of acupuncture in the treatment of Gulf War Illness. Contemp Clin Trials. Feb (33):557-62.. PMID:22349455.

Conboy L.A, St John M, Schnyer R. (2014). Management of Gulf War Syndrome Symptoms with Acupuncture: Findings of a Wait-List Controlled RCT.J Altern Complement Med. 20(5):A15-6.PMID:24805522.

Conboy L.A, Gerke T, Hsu K, StJohn M, Schnyer R. (2016). The Effectiveness of Acupuncture in the Treatment of Gulf War Illness, an Unblinded Phase II Randomized Clinical Trial. PLoS One. Mar 31;11(3):e0149161. doi: 10.1371/journal.pone. 0149161PMID:27031099.

Abou-Donia M.B. Conboy L.A. Kokkotou E., Jacobson E., Elmasry EM, Elkafrawy P, Neely M, Bass CR, Sullivan K. (2017) Screening for novel central nervous system biomarkers in veterans with Gulf War Illness. Neurotoxicol Teratol. 2017 May;61:36-46. doi: 10.1016/j.ntt.2017.03.002. Epub 2017 Mar 9. PMID:28286177.

Alshelh Z, Albrecht DS, Bergan C, Akeju O, Clauw DJ, Conboy L, Edwards RR, Kim M, Lee YC, Protsenko E, Napadow V, Sullivan K, Loggia ML. In-vivo imaging of neuroinflammation in veterans with Gulf War illness. Brain Behav Immun. 2020 Jul;87:498-507. doi: 10.1016/j.bbi.2020.01.020. Epub 2020 Feb 4. PMID: 32027960; PMCID: PMC7864588.

Abou-Donia MB, Lapadula ES, Krengel MH, Quinn E, LeClair J, Massaro J, Conboy LA, Kokkotou E, Abreu M, Klimas NG, Nguyen DD, Sullivan K. Using Plasma Autoantibodies of Central Nervous System Proteins to Distinguish Veterans with Gulf War Illness from Healthy and Symptomatic Controls. Brain Sci. 2020 Sep 5;10(9):610. doi: 10.3390/brainsci10090610. PMID: 32899468; PMCID: PMC7563126.

Abou-Donia MB, Krengel MH, Lapadula ES, Zundel CG, LeClair J, Massaro J, Quinn E, Conboy LA, Kokkotou E, Nguyen DD, Abreu M, Klimas NG, Sullivan K. Sex-Based Differences in Plasma Autoantibodies to Central Nervous System Proteins in Gulf War Veterans versus Healthy and Symptomatic Controls. Brain Sci. 2021 Jan 23;11(2):148. doi: 10.3390/brainsci11020148. PMID: 33498629.


Social Disparities and Integrative Medicine

Conboy L.A., Patel S, Kaptchuk T.J, Gottlieb B, Eisenberg D, Acevedo-Garcia D. (2005). Sociodemographic Determinants of the Utilization of Specific Types of Complementary and Alternative Medicine (CAM): An Analysis Based on a Nationally Representative Survey Sample. Journal of Alternative and Complementary Medicine. 11(6):977-94. PMID: 16398589.

Conboy L.A., Acevedo-Garcia D, Gottlieb R, Eisenberg D, Kaptchuk TJ. (2007). The Relationship Between Social Factors and Attitudes Toward Conventional and CAM Practitioners. Complementary Therapies in Clinical Practice. 13(3):146-157. PMID: 16427366.

Highfield E.S., Spellman L, Barnes LL, Kaptchuk T.J, Paradis G, Conboy L.A., Saper R. (2012). Profile of minority and under-served patients using acupuncture. Complementary Therapies in Medicine. 20: 70-72.


Mindfulness / Integrative Medicine Group Visits and pain

Lutz J, Berry MP, Napadow V, Germer C, Pollak S, Gardiner P, Edwards RR, Desbordes G, Schuman-Olivier Z. Neural activations during self-related processing in patients with chronic pain and effects of a brief self-compassion training - A pilot study. Psychiatry Res Neuroimaging. 2020 Oct 30;304:111155. doi: 10.1016/j.pscychresns.2020.111155. Epub 2020 Jul 30. PMID: 32799058; PMCID: PMC8100920.

Berry MP, Lutz J, Schuman-Olivier Z, Germer C, Pollak S, Edwards RR, Gardiner P, Desbordes G, Napadow V. Brief Self-Compassion Training Alters Neural Responses to Evoked Pain for Chronic Low Back Pain: A Pilot Study. Pain Med. 2020 Oct 1;21(10):2172-2185. doi: 10.1093/pm/pnaa178. PMID: 32783054; PMCID: PMC7593799.

Gardiner P, Luo M, D'Amico S, Gergen-Barnett K, White LF, Saper R, Mitchell S, Liebschutz JM. Effectiveness of integrative medicine group visits in chronic pain and depressive symptoms: A randomized controlled trial. PLoS One. 2019 Dec 18;14(12):e0225540. doi: 10.1371/journal.pone.0225540. PMID:

Bodner K, D'Amico S, Luo M, Sommers E, Goldstein L, Neri C, Gardiner P. A cross-sectional review of the prevalence of integrative medicine in pediatric pain clinics across the United States. Complement Ther Med. 2018 Jun;38:79-84. doi: 10.1016/j.ctim.2018.05.001. Epub 2018 May 4. PMID: 29857885.

Cornelio-Flores O, Lestoquoy AS, Abdallah S, DeLoureiro A, Lorente K, Pardo B, Olunwa J, Gardiner P. The Latino Integrative Medical Group Visit as a Model for Pain Reduction in Underserved Spanish Speakers. J Altern Complement Med. 2018 Feb;24(2):125-131. doi: 10.1089/acm.2017.0132. Epub 2017 Sep 8. PMID: 28885858.

Lestoquoy AS, Laird LD, Mitchell S, Gergen-Barnett K, Negash NL, McCue K, Enad R, Gardiner P. Living with chronic pain: Evaluating patient experiences with a medical group visit focused on mindfulness and non-pharmacological strategies. Complement Ther Med. 2017 Dec;35:33-38. doi: 10.1016/j.ctim.2017.09.002. Epub 2017 Sep 12. PMID: 29154064.

Saper RB, Lemaster C, Delitto A, Sherman KJ, Herman PM, Sadikova E, Stevans J, Keosaian JE, Cerrada CJ, Femia AL, Roseen EJ, Gardiner P, Gergen Barnett K, Faulkner C, Weinberg J. Yoga, Physical Therapy, or Education for Chronic Low Back Pain: A Randomized Noninferiority Trial. Ann Intern Med. 2017 Jul 18;167(2):85-94. doi: 10.7326/M16-2579. Epub 2017 Jun 20. PMID: 28631003; PMCID: PMC6392183.

Gardiner P, Lestoquoy AS, Gergen-Barnett K, Penti B, White LF, Saper R, Fredman L, Stillman S, Lily Negash N, Adelstein P, Brackup I, Farrell-Riley C, Kabbara K, Laird L, Mitchell S, Bickmore T, Shamekhi A, Liebschutz JM. Design of the integrative medical group visits randomized control trial for underserved patients with chronic pain and depression. Contemp Clin Trials. 2017 Mar;54:25-35. doi: 10.1016/j.cct.2016.12.013. Epub 2016 Dec 13. PMID: 27979754.


Data analysis

Connor J. McLaughlin, Efi G. Kokkotou, Jean A. King, Lisa A. Conboy, Ali Yousefi. 2021 Latent Factor Decomposition Model: Applications for Questionnaire Data.