The Musacchio research group is interested in utilizing radical intermediates to find common ground between organic chemistry and chemical biology. Specifically, we are interested in developing radical-mediated methodologies for complex molecule synthesis, identifying new bioconjugation strategies, and establishing radical-mediate biocatalysis systems.
Organic Synthesis; Electron Transfer Processes; Methodology Development; Protei…
Scholarly Work
A Physical Organic Approach to Tuning Reagents for Selective and Stable Methionine Bioconjugation A. H. Christian, S. Jia, W. Cao, P. Zhang, A. T. Meza, M. S. Sigman, C. J. Chang, F. D. Toste, J. Am. Soc. 2019, 141, 0052.
A Radical Approach to the Copper Oxidative Addition Problem: Trifluoromethylation of Bromoarenes
C.C. Le, T. Q. Chen, T. Liang, P. Zhang, D. W. C. MacMillan, Science 2018, 360, 1010.
Metallaphotocatalysis: The Merger of Transition Photocatalysis and Transition Metal Catalysis (Review).
J.R. Twilton, C. C. Le, P. Zhang, M. H. Shaw, R. W. Evans, D. W. C. MacMillan, Nat. Rev. Chem. 2017, 1, 0052.
Silyl Radical Activation of Alkyl Halides in Metallaphotoredox Catalysis: A Unique Pathway for Cross
Electrophile Coupling
P. Zhang, C. C. Le, D. W. C. MacMillan, J. Am. Chem. Soc. 2016, 138, 8084.
General and Expedient Synthesis of 1,4-Dioxygenated Xanthones
A. L. Nichols, P. Zhang, S. F. Martin, Org. Lett. 2011, 13, 4696.
