Understanding the role of the vascular endothelial glycocalyx in the pathogenesis of cardiopulmonary-related diseases is the prime focus of my research. The vascular endothelial glycocalyx layer which covers the luminal side of blood vessels is a good indicator for vascular health. This layer is suspected to be degraded during the onset and progression of cardiopulmonary diseases including acute respiratory distress syndrome and lung cancer.
We develop in vitro and in vivo techniques to introduce various mechanical forces to vascular endothelial cells to mimic the vascular microenvironment during disease. We aim to develop novel therapeutic strategies to regenerate the pulmonary vasculature during various stages of disease.
On the other hand, Professor Mensah also works in the global health space, leading efforts at Therapeutic Innovations Inc. to develop lifesaving medical devices for low to middle-income countries.