1. The first time you start TeXnicCenter, a "Tip of the day" box will pop up. Close it.
2. You will then see the Configuration Wizard.
3. Click on the "Next" button.
4. Tell TeXnicCenter the path to your MiKTeX installation, for example (your path may vary depending on OS Version) C:\Program Files\MiKTeX 2.9\miktex\bin into the text entry field.
5. Click "Next" and you will see that TeXnicCenter has been configured.
6. Click "Finished" and you should be all set.