José M. Argüello
Office Location
Gateway Park 4021
Contact
Phone: 
+1-508-831-4113
José M. Argüello
Professor
Walter and Miriam Rutman Distinguished Professor
Affiliated with: 
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Education: 
Biological Chemist Universidad Nacional de Córdoba, Argentina 1979
PhD (Biological Sciences) Universidad Nacional de Río Cuarto, Argentina 1985
Micronutrient transition metals (copper, zinc, cobalt, nickel, iron, and manganese) play a central role in the interaction of pathogenic (and beneficial) bacteria with higher eukaryote hosts. Our research is directed to understand the bacterial mechanisms of metal homeostasis required for these interactions. In particular, we focus on the functions of transmembrane transporters and chaperone molecules that tightly control metal uptake and distribution. These molecules appear to be key determinants of virulence in pathological bacteria like Mycobacterium tuberculosis and Pseudomonas aeruginosa, or symbionts such as Rhizobium meliloti. In addition, we study the molecular structure and biochemical mechanisms of metal selectivity in transmembrane transport ATPases. Our multidisciplinary approaches include structural and molecular biology, enzymology, biophysics, protein chemistry, fluorescence microscopy, and microbiology. Through a number of ongoing collaborations, we also employ crystallography, X-ray fluorescence and spectroscopy, and bioinformatics to gain insights into the role of metals in bacterial virulence. Collaboration and camaraderie among postdoctoral fellows, graduate students, and undergraduate students are hallmarks of our work. I enjoy mentoring these young colleagues and guiding their progress into a scientific career.
Office Location
Gateway Park 4021
Contact
Phone: 
+1-508-831-4113
Professional Highlights & Honors: 
AAAS Fellow
2017
American Association for the Advancement of Science
Editorial Board Member
2012
Journal of Biogical Chemistry
Award for Outstanding Research and Creative Scholarship
2012
WPI Board of Trustees
NSF Program Director
2009
National Science Foundation
NIH-Research Development Award
1995
National Institutes of Health
Senior Faculty Research Award
2010
Sigma Xi - WPI Chapter
Junior Faculty Research Award
2004
Sigma Xi - WPI Chapter