Professor Shue's expertise lies in network security. He focuses on using system and network measurements to understand what is happening on a network to protect traditional computers and IoT devices. He also builds systems that can detect and prevent attacks to keep organizations and regular Internet users secure. He can speak about all these topics and his research about vulnerabilities in and attacks on multi-factor authentication. Professor Shue has provided analysis for media organizations including NPR and The Associated Press on the July 2024 global technology outage stemming from a defective CrowdStrike software update and for CBS News on the 2025 Amazon Web Services outage that disrupted a variety of online applications and services associated with cloud computing.