Gateway Park 4010
+1 (508) 8315000 x6742
BS Rutgers University 1989
PhD Rutgers University 1996
Postdoc Harvard Medical School 1999

The overall objective of my research is to create bioengineered scaffolds to enhance the regeneration of damaged tissues and organs. Specifically, my laboratory uses biomimetic design strategies and novel fabrication processes to develop three-dimensional constructs that emulate native tissue architecture and cellular microenvironments. We use these scaffolds to characterize the roles of extracellular matrix (ECM) cues and topographic features in modulating cellular functions, including adhesion, migration, proliferation, differentiation, and tissue remodeling. For example, we are investigating the design of microfabricated basement membrane structures to direct keratinocyte function and enhance the performance of bioengineered skin substitutes. We are also designing novel biopolymer microthreads that are being used to deliver stem cells and to facilitate myocardial or skeletal muscle regeneration. These scaffolds have been used, as well, to develop in vitro model systems to predict cellular and tissue responses to implantable biomaterials for the repair of soft tissues including tendon and ligament.

In the classroom, I enjoy teaching students about the fundamentals of biomaterials science and cell-biomaterial interactions used to design implantable biomaterials that promote functional tissue restoration. I particularly enjoying working with teams of students on capstone design projects to develop biomaterials scaffolds and benchtop assays to characterize cell-biomaterial interactions that can be used to solve clinical problems related to wound healing and tissue regeneration. At the graduate level, I enjoy mentoring master’s and doctoral students; helping them develop into independent scientists and engineers who will contribute to solutions of various healthcare problems.

Scholarly Work

10. Crosslinking strategies facilitate tunable structural properties of fibrin microthreads. Grasman JM, Page RL, Dominko T, Pins GD. Acta Biomater. 2012 Nov;8(11):4020-30. doi: 10.1016/j.actbio.2012.07.018. Epub 2012 Jul 21. PMID: 22824528
Multiphoton excited fabricated nano and micro patterned extracellular matrix proteins direct cellular morphology. Pins GD, Bush KA, Cunningham LP, Campagnola PJ. J Biomed Mater Res A. 2006 Jul;78(1):194-204. PMID: 16637027
Cell growth on collagen: a review of tissue engineering using scaffolds containing extracellular matrix. Silver FH, Pins G. J Long Term Eff Med Implants. 1992;2(1):67-80. Review. PMID: 10171194
The Effect of Sterilization Methods on the Structural and Chemical Properties of Fibrin Microthread Scaffolds. Grasman JM, O'Brien MP, Ackerman K, Gagnon KA, Wong GM, Pins GD. Macromol Biosci. 2016 Jun;16(6):836-46. doi: 10.1002/mabi.201500410. Epub 2016 Feb 4. PMID: 26847494
Development of microfabricated dermal epidermal regenerative matrices to evaluate the role of cellular microenvironments on epidermal morphogenesis. Bush KA, Pins GD. Tissue Eng Part A. 2012 Nov;18(21-22):2343-53. doi: 10.1089/ten.TEA.2011.0479. Epub 2012 Jul 30. PMID: 22724677
In vitro comparison of wire and plate fixation for midline sternotomies. Pai S, Gunja NJ, Dupak EL, McMahon NL, Roth TP, Lalikos JF, Dunn RM, Francalancia N, Pins GD, Billiar KL. Ann Thorac Surg. 2005 Sep;80(3):962-8. PMID: 16122464
Professional Highlights & Honors
This team is on the verge of creating a beating Band-Aid for the heart. Just don’t call it goopy

The Boston Globe’s ‘STAT’ section published an article today on WPI research aimed at helping the heart recover after parts of it die from lack of oxygen. “I want to fix people with heart attacks,” George Pins, PhD, associate professor of biomedical engineering, told STAT. “I think it’s an important global health care problem and there’s significant unmet need.”