Research in my lab is focused on investigating signaling mechanisms of neuronal development and genetic basis of rare neurodevelopmental disorders. Specifically, we are interested in studying how specialized cellular compartments called primary cilia modulate development and function of neuronal cell types. Primary cilia are found on the surface of most human cells including neurons, where they function akin to cellular antennae detecting and transmitting a myriad of signaling cues. Due to their central role in cell signaling, primary cilia are critical for normal progression of the developmental program in mammals and play important post-developmental roles in tissue homeostasis. Defects in cilia assembly or function manifest in heterogeneous genetic disorders called ciliopathies that are commonly associated with neurological deficits. Using sophisticated molecular genetics, proteomics, and live imaging approaches in C. elegans with complementary studies in mammalian cell culture models, we aim to identify new genes and map signaling networks that regulate cilia assembly in neurons and define how cilia dysfunction contributes to the onset of neurodevelopmental disorders.
One of the special things about teaching at WPI (and the one that I truly enjoy) is watching students apply outside-the-box thinking to solve problems in the classroom and tackle research questions in lab. Project-based learning, which is at the core of WPI curriculum, cultivates creativity and equips students with the skills to become leaders in their fields, and I feel privileged to be part of their educational journey.
Visit Digital WPI to view student projects and research advised by Professor Nechipurenko.
