PhD in Bioinformatics & Computational Biology
Students in WPI’s bioinformatics program learn cutting-edge approaches in areas such as artificial intelligence (AI) and machine learning, next-generation sequencing, bioinformatics, systems biology, high-performance computing, big data mining, and visualization.
In addition to wet labs and facilities at UMMS, students may access resources in WPI’s Visualization Laboratory, Knowledge Discovery and Data Mining Laboratory, Database Systems Laboratory, and in several powerful computer clusters.
Students apply varied approaches to understand genetic and infectious diseases, prevent ecological disasters, develop new drugs and computational diagnostics tools, and explore new biological phenomena.
Biology, computer science, and mathematics—these disciplines contribute to advances in biological and biomedical science. At WPI, collaboration between disciplines leads to greater discoveries.
Faculty Profiles
My research is interdisciplinary and spans the fields of bioinformatics of complex diseases, computational genomics, systems biology, and biomedical data analytics. We bring expertise in machine learning, data mining, and massive data analytics to study molecular mechanisms underlying genetic disorders, such as cancer, diabetes, and autism, and deadly infections, such as pandemic flu. Our approaches benefit from integrating multi-omic, systems, and structural biology data.
I have a long-standing interest in applying computer science and mathematics to solve biological problems. I am currently the Associate Director of WPI’s Program in Bioinformatics and Computational Biology, and I am always looking for students with interests in this exciting interdisciplinary area. One of my goals in teaching biology is to help students to think more quantitatively about biological questions. A few years ago, my colleague Dr. Brian White of UMass Boston and I were awarded a grant from the NSF to develop a course, “Simulation in Biology”.
Work in my lab is focused on defining the cellular mechanisms that maintain genome stability in normal cells and understanding how these pathways are corrupted in cancer cells.
Carolina Ruiz is the Associate Dean of Arts and Sciences and the Harold L. Jurist ’61 and Heather E. Jurist Dean's Professor of Computer Science. She joined the WPI faculty in 1997. Prof. Ruiz’s research is in Artificial Intelligence, Machine Learning, and Data Mining, and their applications to Medicine and Health. She has worked on several clinical domains including sleep, stroke, obesity and pancreatic cancer. Prof.
I have a passion for understanding how living systems work, as well as for sharing my love of biology and research with the next generation of scientists and informed citizens.
The central goal of my lab is to understand the regulatory mechanisms that underlie mycobacterial stress tolerance. We combine genetics, genomics, transcriptomics and biochemistry to understand how mycobacteria respond to, and ultimately survive, stressful conditions.
Professor Wu's research interest lies in applying the power of statistical science to promote biomedical researches. In statistical genetics, he is developing novel statistical theory and methodology to analyze genome-wide association (GWA) data and deep (re)sequencing data to hunt new genetic factors for complex human diseases. In epigenetics, he is studying gene expression regulation mechanisms through chromatin interaction, and RNA silencing pathways in the developmental stages of germ-line cells.