
Affiliated Department or Office:
Education:
BA Temple University 1979
PhD University of Illinois, Urbana-Champaign 1985
We are interested in learning how small molecules in the blood stream can cause cells to react in specific ways, such as growing, dividing or migrating. While there are many agents that can stimulate or inhibit cell behavior, we are most interested in the ability of certain hormones and neurotransmitters to activate a family of proteins called "G Proteins". G proteins can simulate an enzyme called phospholipase Cbeta (PLCbeta). Activation of PLCbeta raises the level of calcium in the cell, which changes the activity of many other proteins. Additionally, PLCbeta can also affect the ability of a cell to control the transcription of specific genes into proteins by changing the stability of their messenger RNA.
Email
sfscarlata@wpi.edu
Office Location
Gateway Park 3001
Contact
Phone:
+1 (508) 8315000 x6803
Research Lab
Research Interests
Research Interests:
Cell behavior
Calcium signals
Membrane-associated proteins
Membrane properties
G protein signaling
Scholarly Work
Please view complete listing at: http://scarlatalab.wpi.edu/Publications.html
Differential Response to Morphine of the Oligomeric State of Opioid in the Presence of opioid Receptors - 2011
The effect of membrane domains on the G protein phospholipase C signaling pathway - 2010
Evidence for Convergent Evolution in the Signaling Properties of a Choanoflagellate Tyrosine Kinase - 2009
The Pleckstrin Homology Domain of Phospholipase C Transmits Enzymatic Activation through Modulation of the Membrane Domain Orientation - 2006
The use of green fluorescent proteins to view association between phospholipase C beta and G protein subunits in cells - 2004
Professional Affiliations
Professional Affiliations:
Professional Highlights & Honors
Professional Highlights & Honors:
Journal of Biological Chemistry, Analytical Biochemistry, Journal of Bioenergetics and Biomembranes, BBA Biomembranes
American Heart Association
FASEB, ASBMB, Biophysical Society
News

Suzanne Scarlata, Richard Whitcomb Professor of Biochemistry.
November 24, 2020