Faculty Directory

Contact Information

Office:
Life Sciences & Bioengineering Center, 4024
Phone: +1-508-831-6011
Fax: +1-508-831-5936
ryder@wpi.edu

Elizabeth "Liz" F. Ryder

Neurobiology and genetics are my two favorite scientific subjects, and my goal at WPI is to help students discover for themselves how exciting it is to work in these areas. In the classroom, I try to introduce students not only to necessary background knowledge, but also to some of the cutting-edge research going on in these rapidly changing fields.  One of the things I enjoy most about teaching is helping students learn to read the scientific literature. I hope to show students that biology is not about memorizing facts, but rather about asking questions, generating hypotheses, interpreting data, and coming up with exciting new models that can help to explain whatever biological system interests them. 

In my laboratory, we study how neurons navigate during development to reach appropriate locations and make the correct connections to set up a functioning nervous system. My laboratory uses the microscopic worm C. elegans as a model genetic system. Students use transgenic worms to discover how certain types of neurons behave in a normal worm, as well as in various mutant backgrounds. We also use molecular biology and protein biochemistry to understand how proteins involved in this navigation interact with each other.  I am also interested in using computational tools to understand how genes are turned on and off in particular types of cells, and to model cellular interactions in the worm. One exciting aspect of working in a model system is that because of their simplicity, they often lead the way to new understanding of complex biological questions.  Because C. elegans has many genes with functions similar to those of humans, understanding how the nervous system develops in this simple animal contributes to a better understanding of human neurobiology.

One of the reasons I came to WPI is that the university puts so much emphasis on students learning to carry out real research through their MQP work. In the research lab, I really enjoy helping students develop, from novices who simply carry out my instructions, to proficient scientists who can design their own experiments, interpret their results, and put their work in the context of other research in the field. Students used to lab classes that (usually) work are often surprised by how much thought and persistence it can take to get experiments to work in the research lab! When a series of experiments gives us a result that allows us to add to our understanding of the nervous system, it is truly an exhilarating feeling.

Research Interests

  • Developmental Neurobiology
  • Genetics
  • Bioinformatics / Computational Biology

Education

  • A.B. Statistics, Princeton University, 1980
  • M.S. Biostatistics, Harvard School of Public Health, 1985
  • Ph.D. Genetics, Harvard University, 1993

Featured Publications

  • McShea MA, Schmidt KL, Dubuke ML, Baldiga CE, Sullender ME, Reis AL, Zhang S, O'Toole SM, Jeffers MC, Warden RM, Kenney AH, Gosselin J, Kuhlwein M, Hashmi SK, Stringham EG, Ryder EF (2013).  Abelson interactor-1 (ABI-1) interacts with MRL adaptor protein MIG-10 and is required in guided cell migrations and process outgrowth in C. elegans.  Dev Biol. 373:1-13.
  • Wan H, Barrett G, Ruiz C, and Ryder EF (2013). Mining Association Rules that Incorporate Transcription Factor Binding Sites and Gene Expression Patterns in C. elegans (full paper). In Proceedings of the 4th International Conference on Bioinformatics Models, Methods and Algorithms (BIOINFORMATICS 2013). Barcelona, Spain, Feb. 11-14, 2013.
  • Thakkar D, Ruiz C, Ryder EF (2007). Hypothesis Driven Specialization of Gene Expression Association Rules.  In Proceedings of the IEEE International Conference on Bioinformatics and Biomedicine (BIBM2007). pp. 48-55. Fremont, MA. Nov. 2007.
  • Burket CT, Higgins CE, Hull LC, Berninsone PM, Ryder EF (2006).  The C. elegans gene dig-1 encodes a giant member of the immunoglobulin superfamily that promotes fasciculation of neuronal processes.  Dev. Biol. 299:193-205.
  • Quinn CC, Pfeil DS, Chen E, Stovall EL, Harden MV, Gavin MK, Forrester WC, Ryder EF, Soto MC, Wadsworth WB (2006).  UNC-6/netrin and SLT-1/slit guidance cues orient axon outgrowth mediated by MIG-10/RIAM/lamellipodin.  Current Biology 16: 845-53.

 

Professional Highlights

  • The role of MRL adaptor protein MIG-10 in neuronal migration in C. elegans.  NIH AREA Award R15NS0645961.  5/15/2010 – 4/30/2012.
  • Simulation in Biology Education.  WPI Educational Development Council Award, 2010-2011.
  • Sensory Map Formation in the Nervous System of C. elegans.  National Science Foundation CAREER Award.  NSF 9984662. 3/1/2000—2/28/2005.
  • 6 MQP projects I advised have won the Provost’s MQP Award for Biology and Biotechnology (1996-2010).
 
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