BCB Grad Seminar
"Examining Host-Fungal Pathogen Interactions: A Study with Candida albicans and macrophages"
Toni Delorey, BBT PhD student
Abstract: Candida albicans is an opportunistic human pathogen associated with high rates of morbidly and mortality. Increasingly, Candida species are developing resistance to the major class of drugs available to treat fungal infections. We’ve created an in vitro infection system which allows simultaneous measurement of host and fungal pathogen transcriptional signal from distinct infection fates via RNA-sequencing. Additionally, we are able to isolate single, infected macrophages to characterize transcriptional heterogeneity within sample populations. Ultimately, we believe the data generated with this tool can guide the development of novel fungal therapeutics.
Thursday, October 12, 2017