BIOLOGY AND BIOTECHNOLOGY SEMINAR:
"Transcriptional regulation in mycobacteria"
Dr. Eric Galburt, Assistant Professor Biochemistry & Molecular Biophysics
Washington University in St. Louis
Host: Assistant Professor Scarlet Shell
Abstract: While mechanisms of bacterial transcription in E. coli have been studied for many decades, it is becoming clear that different bacteria may use different regulatory strategies with which to control gene expression. For example, Mycobacterium tuberculosis lacks some well-known E. coli regulatory factors (i.e. Fis, DksA, and UP-elements) and possesses two transcription factors that have no homologues in E. coli, namely CarD and RbpA. Both of these factors are essential for growth in culture and CarD is known to be essential for Mtb infection in mice models. Both CarD and RbpA appear to play important roles during the formation of the open complex intermediate during transcription initiation, particularly on ribosomal rRNA promoters. We are interested in the molecular mechanisms of these two factors and the regulatory pathways that they may support.
Monday, November 28, 2016