Distinguished Lecture Series in Biomedical Engineering
Monday, September 19, 2022 12:00pm to 12:50pm
BME Seminar Series: "Navigating the Brain and Spine - Stepping Outside of our Comfort Zone" by Arno Sungarian, MD, FAANS| UMass Medical School
Arno Sungarian, MD, FAANSAssistant Professor of SurgeryNeurological SurgeryUniversity of Massachusetts Medical School
NAVIGATING THE BRAIN AND SPINE - STEPPING OUTSIDE OF OUR COMFORT ZONEAbstract: Surgery of the brain and spine has seen an explosive growth in the last half a century due to innovation in surgical techniques and introduction of new technologies to improve patient care and outcomes. The volume of cases has continued to rise as has the expectation for better outcomes and faster recovery in the realm of increased socioeconomic pressures. More complex procedures are performed in an outpatient setting with minimally invasive techniques becoming more desirable. AR and VR technologies are becoming an integral part of the surgeons arsenal and AI will eventually replace the surgeon all together.My goal is to open a broad discussion about emerging trends in the surgery of the brain and spine as a stepping stone for new ideas and their practical implementation.Biography: Dr.Arno Sungarian was born in Plovdiv, Bulgaria in 1967. He attended English Language High School and 2 years of compulsory military service in the ‘80s. Immigrated to the US in 1990, after the collapse of the Soviet Union.Dr.Sungarian obtained a Bachelor of Science degree from Columbia University in NYC 1991-93, and a Medical Degree at Brown University, 1993-97. His residency was in Neurosurgery at Brown/Rhode Island Hospital from 1997 to 2004. He has been practicing Neurosurgery in Worcester since 2004. He is married with 2 kids, 13 and 15, and lives in Shrewsbury, MA
Monday, September 26, 2022 12:00pm to 12:50pm
BME Seminar Series: Generation of Complex Three-Dimensional Organ Tissue Models for Drug Discovery and disease modeling| Seyoum Ayehunie, Ph.D| MatTek Corporation | a Bico Company
Seyoum Ayehunie, Ph.DChief Scientific OfficerMatTek Corporation | a Bico Company
Tittle: Generation of Complex Three-Dimensional Organ Tissue Models for Drug Discovery and disease modeling
Abstract: Currently available in vitro 2D-cell based drug screening models are neither organ nor species-specific relying predominantly on the use of monolayer cell lines. These models lack the structural complexity of tissues or organs. 2D monolayers cell culture systems do not recapitulate the physiology microenvironment of the native human organs and do not adequately predict safety and efficacy of drugs/chemicals. Animal models also have fundamental problems since they are genetically different and do not adequately recapitulate human physiology. In this talk, the utility and limitations of a novel in vitro complex 3D tissue-models, generated using standard techniques or bioprinting, in drug absorption, metabolism, prediction of toxicity, and disease modeling will be highlighted. Study results of therapeutic compounds for which dog and rat studies were not predictive of human outcome will also be discussed.
Biography: Prior to joining MatTek, Dr. Ayehunie, who received his PhD from the Karolinska Institute, Stockholm, Sweden, did his post-doctoral fellowship at Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA (1993-1997). At Harvard Dr. Ayehunie was involved in HIV vaccine research and received the Fogarty International and NIH fellowship awards and also appointed as an instructor of Medicine. Dr. Seyoum Ayehunie is currently, Chief Scientific Officer at MatTek Corporation, a BICO company, Ashland, MA, and is the lead scientist for all R&D research. He has developed multiple in vitro primary human cell-based organotypic tissue models for predicting safety and efficacy of drug candidates, chemicals, and formulations. In addition, he has received more than 20 Small Business Innovation Research (SBIR Phase I and Phase II) grant awards from the National Institute of Health (NIH) and the Department of Defense (DoD). Dr. Ayehunie has served as permanent member of NIH Study Sections. He has more than 50 publications in refereed journals to his credit and has made a number of presentations in international conferences and collaborated with academic institutions including WPI.View Event
Monday, October 03, 2022 12:00pm to 12:50pm
BME Seminar Series: David Kennedy, Ph.D| Repronim: Towards Reproducible Neuroimaging Neuroscience| UMass Medical School
David Kennedy, Ph.DProfessor of Psychiatry, University of Massachusetts Medical SchoolDirector of the Division of NeuroinformaticsChild and Adolescent Neurodevelopment Initiative
ReproNim: Towards Reproducible Neuroimaging Neuroscience
Abstract: Given the intrinsically large and complex data sets collected in neuroimaging research, coupled with the extensive array of shared data and tools amassed in the research community, ReproNim seeks to lower the barriers for efficient: use of data; description of data and process; use of standards and best practices; sharing; and subsequent reuse of the collective ‘big’ data. Aggregation of data and reuse of analytic methods have become critical in addressing concerns about the replicability and power of many of today’s neuroimaging studies.
Biography: Dr. David Kennedy is a Professor of Psychiatry at the University of Massachusetts Medical School. He is Director of the Division of Neuroinformatics at the Child and Adolescent Neurodevelopment Initiative (CANDI). He has extensive expertise in the development of image analysis techniques and was a co-founder of the Center for Morphometric Analysis (CMA) at the Massachusetts General Hospital. His career has seen participation in the advent of such technologies as MRI-based morphometric analysis (1989), functional MRI (1991) and diffusion tensor pathway analysis (1998). He has long standing experience with development of neuroinformatics resources and participated in the morphometry Biomedical Informatics Research Network (mBIRN). Dr. Kennedy is a co-PI and community liaison for the Neuroimaging Informatics Tools and Resources Clearinghouse (NITRC). In addition, he is a founding editor of the journal Neuroinformatics that debuted in 2003, and PI of ReproNim: A Center for Reproducible Neuroimaging Computation.
Monday, October 24, 2022 12:00pm to 12:50pm
BME Seminar Series: "Lipid-Based Systems: From Therapeutics To In Vitro Models" by Christina M. Bailey-Hytholt, Ph.D| Assistant Professor| Chemical Engineering
Christina Bailey-Hytholt, PhDAssistant ProfessorDepartment of Chemical EngineeringWorcester Polytechnic Institute
LIPID-BASED SYSTEMS: FROM THERAPEUTICS TO IN VITRO MODELS
Abstract: Lipid constructs are ubiquitous and advancing healthcare technologies through advancements in therapeutics and in vitro model systems. Lipid nanoparticles (LNPs) and liposomes serve as delivery vehicles for nucleic acids and small molecules by improving transfection efficiency, targeting, and stability of their loaded cargo. Additionally, lipid structures, including lipid vesicles and lipid bilayers, are useful tools to understand molecular interactions at biological interfaces. This talk will discuss strategies for using lipids for both therapeutic and in vitro model applications. Methods to manufacture LNPs and liposomes, characterization, and in vitro studies will be discussed for messenger RNA (mRNA) and plasmid DNA (pDNA) loaded LNPs and antifungal loaded liposomes. Additionally, this talk will discuss the formation and use of multi-lipid bilayers representative of placental trophoblast lipid bilayers for pharmaceutical and environmental toxicant interaction studies.
Biography: Dr. Christina Bailey-Hytholt is an Assistant Professor of Chemical Engineering at Worcester Polytechnic Institute. Her research focuses on designing biomaterials for applications in drug and gene delivery, in vitro model systems, and diagnostics with a broad interest in applications for women’s health. She is the recipient of several honors and awards for both her research and teaching, including a Career Development Award from the Biomedical Engineering Society and a Women in Chemical Engineering Travel Award from the American Institute for Chemical Engineers. Most recently, Dr. Bailey-Hytholt was selected as one of Forbes’ 30 under 30 in Science for 2022. Prior to joining WPI, Dr. Bailey-Hytholt was a Postdoctoral Fellow in the Biologics Drug Product Development & Manufacturing group at Sanofi. She received her Ph.D. in Biomedical Engineering from Brown University in 2020 as an NSF Graduate Research Fellow, and she was awarded Brown University’s Presidential Award for Excellence in Teaching as well as Brown University’s School of Engineering Outstanding Thesis Award. She received her B.S. in Chemical Engineering at WPI in 2015.
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Monday, November 14, 2022 12:00pm to 12:50pm
BME Distinguished Lecture Series: Light and Sound: Integrating Photonics with Ultrasonics| Matthew O'Donnell, PhD| University of Washington
Matthew O'Donnell, Ph.DFrank and Julie Jungers Dean EmeritusProfessorDepartment of BioengineeringUniversity of Washington
Light and Sound: Integrating Photonics with Ultrasonics
Abstract: Coherent light and sound have become essential tools in modern medicine. Lasers are routinely used for both therapeutic and diagnostic applications, and real-time ultrasound scanning has become the dominant biomedical imaging modality in the world. Starting over thirty years ago, scientists and engineers have combined these modalities for applications ranging from non-contact sensing to novel molecular imaging techniques. In this talk, I will explore the history of integrated photonic-ultrasonic systems, focusing on examples where light generates sound, light detects sound, and sound “tickles” light. I will also present specific applications of integrated photonic-ultrasonic techniques, including photoacoustics for molecular imaging, non-contact laser ultrasound systems for medical and non-medical applications, and optical coherence elastography (OCE) in which air-coupled ultrasound stimulates propagating shear waves in the eye and skin tracked with real-time, 3-D optical coherence tomography (OCT). The talk will conclude by discussing current barriers to clinical translation of these systems and possible ways to overcome the obstacles.
Biography: Following undergraduate, graduate, and post-doctoral training at Notre Dame and Washington University in St. Louis, Dr. O’Donnell joined General Electric Corporate Research and Development Center in Schenectady, NY in 1980, where he worked on medical electronics, including MRI and ultrasound imaging systems. In 1990, he moved to University of Michigan in Ann Arbor, MI where he held appointments in Electrical Engineering & Computer Science and in Biomedical Engineering. In 1998, he was named the Jerry W. and Carol L. Levin Professor of Engineering. From 1999-2006 he also served as Chair of the Biomedical Engineering Department. In 2006 he moved to the University of Washington in Seattle, WA where he was the Frank and Julie Jungers Dean of Engineering from 2006-2012. He is now Frank and Julie Jungers Dean Emeritus and a Professor of Bioengineering at the University of Washington. His most recent research has explored new imaging modalities, including elasticity imaging, in vivo microscopy, optoacoustic devices, photoacoustic contrast agents for molecular imaging and therapy, laser ultrasound systems, and catheter-based devices. He has won numerous awards, including the Distinguished Alumni Award from the University of Notre Dame, the Achievement and Rayleigh Awards from the IEEE-UFFC Society, the William J. Morlock Award for Excellence in Biomedical Technology from the IEEE-EMBS Society, and the IEEE Biomedical Engineering Award. He is a fellow of the IEEE and AIMBE and is an elected member of the Washington State Academy of Sciences and the National Academy of Engineering.
Monday, November 28, 2022 12:00pm to 12:50pm
BME Seminar Series: Steven Zanganeh, Ph.D| Assistant Professor| Bioengineering Department | UMass Dartmouth
Steven Zanganeh,PhDAssistant ProfessorBioengineering DepartmentUMass DartmouthView Event
Monday, December 12, 2022 12:00pm to 12:50pm
BME Distinguished Lecture Series: Pcpe2- linking Cholesterol Metabolism, Obesity and Fibro-inflammatory Precursors| Mary Sorci-Thomas, PhD| Medical College of Wisconsin
Mary Sorci-Thoma, PhDProfessor of MedicineAssociate Director of Cardiovascular CenterProgram Director, CVC T32 Training ProgramMedical College of Wisconsin
Tittle: Pcpe2- linking Cholesterol Metabolism, Obesity and Fibro-inflammatory PrecursorsView Event
Monday, February 13, 2023 12:00pm to 12:50pm
BME Distinguished Lecture Series: Polymer Strategies in Musculoskeletal Tissue Engineering| Elizabeth Cosgriff-Hernandez, PhD| The University of Texas at Austin