Microbial Fermentation Development, Scale-up, and Manufacturing

Tuesday, June 19, 2018 to Friday, June 22, 2018
8:30 am to 4:00 pm
Biomanufacturing Education & Training Center
50 Prescott Street
Worcester, MA 01609
United States

The successful implementation of microbial fermentation technology requires optimization of a number of variables. A clear understanding of all aspects of this technology assures that upstream scientists and technicians are capable and confident in their handling of these processes.

This course employs extensive hands-on laboratory work using both single-use and stainless steel equipment. Participants will thaw seed vials and perform scale-up operations from a shake flask to a bench top fermenter, to a pilot scale fermenter. Participants will also learn the fundamentals of microbial growth, cell line development and media composition and selection.


  • Understand the principles of microbial growth and growth kinetics
  • Understand what the various media components are and their functionality
  • Understand protein expression and production
  • Identify the critical components of fermenters: how they work and are used
  • The setup, preparation, sterilization and inoculation of a fermenter
  • Understand how mixing studies are performed and why
  • Understand the critical attributes to consider during scale-up
  • Define the procedures employed to harvest the fermenter
  • Learn the above in a simulated GMP environment following SOPs

This class is limited to 24 students – reserve your seat early to avoid being waitlisted.


  • Program Start: June 19-22, 2018
  • Registration Deadline:  two weeks prior to program start
  • Time: 8:30 a.m.to 4:00 p.m.
  • CEU: 2.8
  • There are no academic prerequisites for this program
  • Visit the link below for more information and cost of the program.