Master’s in Biology and Biotechnology

Our lab investigates the molecular basis of phenotype switching in human fibroblasts that can be modulated using defined extracellular stimuli. We evaluate the role of oxygen and growth factor FGF2 isoforms independently and in combination in order to identify key molecular mechanisms and pathways, some of which closely mimic mechanisms described in human embryonic stem cells. Extended lifespan of these cells in culture also offers us a model for investigation of molecular mechanism that are regulating cell cycle in the context of both aging and cancer.

Work in my lab is focused on defining the cellular mechanisms that maintain genome stability in normal cells and understanding how these pathways are corrupted in cancer cells.

My research program focuses on understanding and managing fungal diseases. We primarily study Candida albicans, an opportunistic pathogen and the most prevalent fungal pathogen of humans. It is responsible for common clinical problems including oral thrush and vaginitis, but can also lead to life-threatening systematic infections in immunocompromised individuals such as AIDS patients, resulting in 30-50% mortality rates. The estimated annual cost of treating nosocomial Candida infections exceeds $1 billion per year.

It has been my lifelong dream to become a professor in the field of Biology. Being a faculty member provides a great opportunity to teach and interact with students. Students by nature are highly inquisitive and motivated, and as teachers, we have the responsibility to guide our students to explore and think in new ways. I believe that teaching is a two-way interaction between teachers and students. I come from India and my parents, both of whom were teachers, taught me to strive for excellence in my scholarly pursuits.