As a PhD student in WPI’s Biology and Biotechnology program, you will benefit from close mentorship by dynamic faculty who encourage creativity and inquisitiveness.
Enabled by a world-class research infrastructure, students in our competitive program explore their passion for discovery while driving cutting-edge, hypothesis-driven research. You will work alongside interdisciplinary teams of WPI faculty, peers, and industry partners to make an impact in your field and explore topics that matter to you, from cancer biology and immunology research to studies of brain plasticity and pollinator decline.
Through our well-rounded PhD program, you will delve into immersive research in biology and biotechnology while also sharpening your professional and pedagogical knowledge and skills. You will take core courses covering professional ethics, grant writing, and experimental design, and hone your communication skills by participating in department-wide research presentations. You may also take part in supervised teaching experiences and discuss interdisciplinary research initiatives in our Journal Clubs.
Students complete a qualifying exam by the end of the second year of study and round out required coursework with electives. Completion of PhD studies concludes with the preparation of a written thesis and successful oral defense.
WPI’s Department of Biology and Biotechnology is home to a diverse and dynamic faculty body that employs cutting-edge research to explore and understand research topics at the intersection of biology and technology. You will work alongside them as you make your own discoveries in these research areas:
PhD candidates are encouraged to review the department's faculty pages to identify potential advisors.
You will have access to state-of-the-art equipment in WPI’s Life Sciences and Bioengineering Center, a research complex where an open-plan lab and presence of biotech companies encourage interdisciplinary collaborations. Facilities include an analytical instrumentation core equipped for NMR, Mass Spec, X-Ray Crystal, and qPCR analysis; imaging core with advanced microscopes for point-scanning confocal, spinning disk confocal, and TIRF microscopy; and AAALAC-accredited vivarium.
Work in my lab is focused on defining the cellular mechanisms that maintain genome stability in normal cells and understanding how these pathways are corrupted in cancer cells.
Defining signaling pathways that program cellular diversity is one of the foremost problems in biology and is central to my research interests. In the lab we use molecular, genetic, and biochemical approaches to characterize the function of these pathways and to gain insight into their role in disease. To date, the lab has focused on the Epidermal Growth Factor Receptor network, a principal therapeutic target for a variety of human cancers.
I deeply enjoy teaching, in particular conveying the important roles played by plants. It is a great reward when my students realize that plants are more complex and interesting than they anticipated, and they want to learn more. I enjoy that students at WPI are open about thinking in new ways; this critical thinking is the result of intense project-based learning.
Prof. Weathers is an internationally recognized expert on Artemisia annua and artemisinin, having worked with the plant and its phytochemicals including the antimalarial drug, artemisinin, for >25 years. She is a Fellow of AAAS and SIVB, won many awards, given many national and international presentations, reviews manuscripts for many journals and proposals for many national and international funding agencies. She is an Associate Editor for two journals. Her lab was the first to genetically transform A. annua.
Our lab investigates the molecular basis of phenotype switching in human fibroblasts that can be modulated using defined extracellular stimuli. We evaluate the role of oxygen and growth factor FGF2 isoforms independently and in combination in order to identify key molecular mechanisms and pathways, some of which closely mimic mechanisms described in human embryonic stem cells. Extended lifespan of these cells in culture also offers us a model for investigation of molecular mechanism that are regulating cell cycle in the context of both aging and cancer.
My research interests broadly focus on the molecular biology of mRNA translational control – or more simply put, “why” and “how” cells regulate the translation of their mRNAs into proteins. I am particularly interested in translational control as it relates to the cellular stress response. When cells are stressed by environmental factors, such as energy deprivation, heavy metal poisoning, or extreme temperatures, they will conserve resources by restricting mRNA translation.
Research in my laboratory addresses questions in the field of evolutionary ecology and environmental biology, and typically combines field work and laboratory studies. Current projects focus on two disciplines.
My research program focuses on understanding and managing fungal diseases. We primarily study Candida albicans, an opportunistic pathogen and the most prevalent fungal pathogen of humans. It is responsible for common clinical problems including oral thrush and vaginitis, but can also lead to life-threatening systematic infections in immunocompromised individuals such as AIDS patients, resulting in 30-50% mortality rates. The estimated annual cost of treating nosocomial Candida infections exceeds $1 billion per year.
I have a passion for understanding how living systems work, as well as for sharing my love of biology and research with the next generation of scientists and informed citizens.
The central goal of my lab is to understand the regulatory mechanisms that underlie mycobacterial stress tolerance. We combine genetics, genomics, transcriptomics and biochemistry to understand how mycobacteria respond to, and ultimately survive, stressful conditions.
It has been my lifelong dream to become a professor in the field of Biology. Being a faculty member provides a great opportunity to teach and interact with students. Students by nature are highly inquisitive and motivated, and as teachers, we have the responsibility to guide our students to explore and think in new ways. I believe that teaching is a two-way interaction between teachers and students. I come from India and my parents, both of whom were teachers, taught me to strive for excellence in my scholarly pursuits.
