PhD in Biology and Biotechnology

Work in my lab is focused on defining the cellular mechanisms that maintain genome stability in normal cells and understanding how these pathways are corrupted in cancer cells.

Defining signaling pathways that program cellular diversity is one of the foremost problems in biology and is central to my research interests.  In the lab we use molecular, genetic, and biochemical approaches to characterize the function of these pathways and to gain insight into their role in disease.  To date, the lab has focused on the Epidermal Growth Factor Receptor network, a principal therapeutic target for a variety of human cancers.

I deeply enjoy teaching, in particular conveying the important roles played by plants. It is a great reward when my students realize that plants are more complex and interesting than they anticipated, and they want to learn more. I enjoy that students at WPI are open about thinking in new ways; this critical thinking is the result of intense project-based learning.

Prof. Weathers is an internationally recognized expert on Artemisia annua and artemisinin, having worked with the plant and its phytochemicals including the antimalarial drug, artemisinin, for >25 years. She is a Fellow of AAAS and SIVB, won many awards, given many national and international presentations, reviews manuscripts for many journals and proposals for many national and international funding agencies. She is an Associate Editor for multiple journals. Her lab was the first to genetically transform A. annua.

Our lab investigates the molecular basis of phenotype switching in human fibroblasts that can be modulated using defined extracellular stimuli. We evaluate the role of oxygen and growth factor FGF2 isoforms independently and in combination in order to identify key molecular mechanisms and pathways, some of which closely mimic mechanisms described in human embryonic stem cells. Extended lifespan of these cells in culture also offers us a model for investigation of molecular mechanism that are regulating cell cycle in the context of both aging and cancer.

My lab works broadly in the emerging field of synthetic biology. Synthetic biology seeks to apply engineering design principles to the understanding and creation of biological systems. I use synthetic biology to design biosensors and bioremediation strategies for various environmental contaminants that impact human health, including lead, arsenic, and other toxic substances. We apply the tools of synthetic biology to address global challenges related to water, soil, and human health.

Research in my laboratory addresses questions in the field of evolutionary ecology and environmental biology, and typically combines field work and laboratory studies. Current projects focus on two disciplines.

A member of the WPI faculty since 2004 and chair of the Department of Biology and Biotechnology since 2022, Reeta Rao is a leader in the field of molecular genetics and genomics. Her primary research activities are focused on emerging infectious diseases, specifically understanding and managing fungal diseases. Students and research associates in her laboratory are trained to use a variety of biochemical, molecular-genetic, and genomic tools to study host-microbe interactions to explore fungal virulence strategies and identify novel therapeutic

I have a passion for understanding how living systems work, as well as for sharing my love of biology and research with the next generation of scientists and informed citizens.

The central goal of my lab is to understand the regulatory mechanisms that underlie mycobacterial stress tolerance. We combine genetics, genomics, transcriptomics and biochemistry to understand how mycobacteria respond to, and ultimately survive, stressful conditions.

It has been my lifelong dream to become a professor in the field of Biology. Being a faculty member provides a great opportunity to teach and interact with students. Students by nature are highly inquisitive and motivated, and as teachers, we have the responsibility to guide our students to explore and think in new ways. I believe that teaching is a two-way interaction between teachers and students. I come from India and my parents, both of whom were teachers, taught me to strive for excellence in my scholarly pursuits.