Faculty & Staff
Program Director - Sam Walcott
Email: swalcott@wpi.edu
Phone: +1 (508) 8315000 x6877
I use physical principles at the molecular scale to solve macroscopic problems in biology, e.g. How do a molecule's mechanical properties influence the behavior of a cell? How do single molecule measurements relate to muscle function? To answer such questions, I use a combination of computer simulations and mathematical analysis. This theoretical work is complemented by experiments performed by my collaborators. In my teaching, I enjoy emphasizing connections between math and other disciplines.
view profileAssociate Program Director - Amity Manning
Email: almanning@wpi.edu
Phone: +1 (508) 8315000 x4961
Work in my lab is focused on defining the cellular mechanisms that maintain genome stability in normal cells and understanding how these pathways are corrupted in cancer cells. Genomic instability is a feature common in cancer that leads to aneuploidy and intra-tumor heterogeneity. Whole chromosome instability (CIN) results from underlying defects in mitotic chromosome segregation and leads to gains and losses of entire whole chromosomes. The ability of CIN cancer cells to ‘shuffle’ their genomic content can lead to gains of oncogenes, loss of tumor suppressors, and promotes tumor cell ...
view profileBCB Steering Committee
Email: anarnold@wpi.edu
Phone: +1 (508) 8315000 x6825
My research focuses on inverse problems and uncertainty quantification, incorporating elements of applied and computational mathematics, statistics, and scientific computing. Broadly speaking, inverse problems involve finding the unknown causes of observed effects, and uncertainty quantification plays a key role in understanding the reliability of predicted effects due to variability in the causes. In the problems that I consider, these causes are typically the unknown inputs (or parameters) of a system, and the effects are some partial, noisy observations of the system components. The ...
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Email: rdempski@wpi.edu
Phone: +1 (508) 8315000 x4193
Our research integrates investigating the structure and function of targeted membrane proteins with development of mixed reality tools for workforce development. We combine biochemical and biophysical techniques to investigate the structure and function of two classes of membrane proteins. In the first instance, we are investigating the mechanism of a zinc transporter, hZIP4. This protein has been implicated in the initiation and progression of pancreatic cancer. Despite the central role of this protein in cellular homeostasis, the mechanism of cation transport is not well understood. ...
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Email: nfarny@wpi.edu
Phone: +1 (508) 8315000 x6511
My lab works broadly in the emerging field of synthetic biology. Synthetic biology seeks to apply engineering design principles to the understanding and creation of biological systems. I use synthetic biology to design biosensors and bioremediation strategies for various environmental contaminants that impact human health, including lead, arsenic, and other toxic substances. We apply the tools of synthetic biology to address global challenges related to water, soil, and human health. Our water and soil applications focus around understanding how we can use genetically engineered microbes ...
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Email: dkorkin@wpi.edu
Phone: +1 (508) 8315000 x4916
My research is interdisciplinary and spans the fields of bioinformatics of complex diseases, computational genomics, systems biology, and biomedical data analytics. We bring expertise in machine learning, data mining, and massive data analytics to study molecular mechanisms underlying genetic disorders, such as cancer, diabetes, and autism, and deadly infections, such as pandemic flu. Our approaches benefit from integrating multi-omic, systems, and structural biology data. We also develop hardware-optimized algorithms to understand the evolution of animal and plant genomes on the large scale. ...
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Email: ruiz@wpi.edu
Phone: +1 (508) 8315000 x5640
Carolina Ruiz is the Associate Dean of Arts and Sciences and the Harold L. Jurist ’61 and Heather E. Jurist Dean's Professor of Computer Science. She joined the WPI faculty in 1997. Prof. Ruiz’s research is in Artificial Intelligence, Machine Learning, and Data Mining, and their applications to Medicine and Health. She has worked on several clinical domains including sleep, stroke, obesity and pancreatic cancer. Prof. Ruiz and her research group have developed novel, high-performing machine learning methods, including deep learning networks, for analyzing physiological sleep data; and machine ...
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Email: bservat@wpi.edu
Phone: +1 (508) 8315000 x5361
What is a better way of learning, soaking knowledge up like a sponge or like a sieve? A sponge may be saturated quickly, while an appropriate sieve retains the valuable and discards the superfluous. The essence of teaching is to enable the student to recognize the jewels in a subject, unearth them, and create a valuable collection.
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Email: lvidali@wpi.edu
Phone: +1 (508) 8315000 x4194
I deeply enjoy teaching, in particular conveying the important roles played by plants. It is a great reward when my students realize that plants are more complex and interesting than they anticipated, and they want to learn more. I enjoy that students at WPI are open about thinking in new ways; this critical thinking is the result of intense project-based learning. My research aims at understanding the molecular and cellular mechanisms underlying plant cell organization and growth, with the long-term goal of increasing plant productivity. I am particularly interested in understanding the ...
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Email: emyoung@wpi.edu
Phone: +1 (508) 8315000 x6398
My research is in the broad, interdisciplinary field of synthetic biology, which applies engineering principles to biology. Within this field, we apply chemical engineering tenets to reprogram the DNA of yeasts, bacteria, and fungi so their metabolism produces interesting molecules. By treating these cells as "chemical factories," we can approach and solve problems in biofuels, biomaterials, and biosensors from a chemical engineer's point of view. Our strengths are in the disciplines of metabolic engineering, protein engineering, and systems biology, which we use to construct novel synthetic ...
view profileBCB Faculty
Email: emmanuel@wpi.edu
Phone: +1 (508) 8315000 x5568
Emmanuel Agu is currently a professor in the computer science department at WPI having received his Masters and PhD in electrical and computer engineering at the University of Massachusetts at Amherst. His research interests are in the areas of computer graphics, mobile computing, and wireless networks. He is especially interested in research into how to use a smartphone as a platform to deliver better healthcare. In collaboration with researchers at WPI and at UMass Medical School, he is currently working on NIH-funded research project to create a mobile application for chronic wound care ...
view profileEmail: jbourgeois@wpi.edu
Phone: +1 (508) 8315000 x5160
The Bourgeois Lab strives to understand how pathogens and their hosts interact. Specifically, we leverage natural diversity (pathogen and host diversity) to understand how and why we observe variation in infection-related phenomena (e.g. inflammation, transmission, disease severity). Our work primarily involves studying the atypical Gram negative spirochete that causes Lyme disease--Borrelia burgdorferi. A B. burgdorferi infection is acquired through an infected Ixodes tick bite and can manifest in a wide range of symptoms, including erythema migrans, arthritis, carditis, or neurological ...
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Email: jduffy@wpi.edu
Phone: +1 (508) 8315000 x5579
Defining signaling pathways that program cellular diversity is one of the foremost problems in biology and is central to my research interests. In the lab we use molecular, genetic, and biochemical approaches to characterize the function of these pathways and to gain insight into their role in disease. To date, the lab has focused on the Epidermal Growth Factor Receptor network, a principal therapeutic target for a variety of human cancers. This work involved the characterization of Kekkon1 (Kek1), an archetypal LIG molecule, as a novel feedback inhibitor of the EGFR network. ...
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Email: cfowler@wpi.edu
My research seeks to apply causal inference and data science methods to intensive longitudinal data while addressing issues of missingness, non-stationarity, and latent variables. This work is motivated by mobile studies that employ wearable devices or smartphones to collect data and applications to improve understanding of mental health and health disparities. I am passionate about increasing accessibility and diversity in the field of statistics. Please visit my website to learn more about my research and teaching.
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Email: smcinally@wpi.edu
Phone: +1 (508) 8315000 x6291
Shane McInally is an assistant professor in the Department of Biology and Biotechnology. His research focuses on understanding the molecular and physical mechanisms that cells use to control and scale the size of their internal structures with distinct aspects of their geometry. He received a BS from the University of California, Riverside, an MPH from the University of California, Berkeley, and a PhD from the University of California, Davis. Most recently he was a postdoctoral fellow in the Biology and Physics Departments at Brandeis University.
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Email: anarunsky@wpi.edu
Phone: +1 (508) 8315000 x6366
Aya Narunsky is a computational biochemist focusing on the molecular evolution of proteins and RNA. She completed her PhD at Tel Aviv University under the mentorship of Prof. Nir Ben-Tal, where she became fascinated with origin-of-life research through her studies on the evolution of protein-ligand interactions. She then joined the lab of Prof. Ronald Breaker at Yale University as a postdoctoral researcher, where she led the computational discovery and characterization of novel noncoding RNAs in bacteria. Her work revealed that some of these ancient RNAs may also control essential biological ...
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Email: inechipurenko@wpi.edu
Phone: +1 (508) 8315000 x6314
Research in my lab is focused on investigating signaling mechanisms of neuronal development and genetic basis of rare neurodevelopmental disorders. Specifically, we are interested in studying how specialized cellular compartments called primary cilia modulate development and function of neuronal cell types. Primary cilia are found on the surface of most human cells including neurons, where they function akin to cellular antennae detecting and transmitting a myriad of signaling cues. Due to their central role in cell signaling, primary cilia are critical for normal progression of the ...
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Email: bnephew@wpi.edu
I work with Dr. Jean King, where our research is broadly focused on identifying and studying neurobehavioral mechanisms of mental and physical illness and developing and applying effective interventions. Our current focus is a 9 million dollar NIH UG3/UH3 award to use machine learning to identify predictors of responders to mindfulness meditation based interventions for chronic low back pain using comprehensive biopsychosocial data, including Fitbit data. This research initiative includes collaborators at Boston Medical Center and UMass Chan Medical School in addition to several WPI faculty. ...
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Email: sdolson@wpi.edu
Phone: +1 (508) 8315000 x4940
At WPI, I enjoy teaching all courses fundamental to applied mathematics, scientific computing, and modeling. I look forward to mentoring students interested in working on areas in Mathematical Biology, Computational Biofluids, and Scientific Computing. I specialize in Mathematical Biology, understanding emergent properties of complex systems. The goals of these models are to understand the underlying biological processes and make predictions. Please visit my website to learn more about recent research projects.
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Email: rcpaffenroth@wpi.edu
Phone: +1 (508) 8315000 x6562
My research focuses on compressed sensing, machine learning, signal processing, and the interaction between mathematics, computer science and software engineering. My interests range from theoretical results to algorithms for tackling practical applied problems, and I enjoy problems most when mathematical results lead to efficient software implementations for big data. I am looking forward to working with students at all levels and backgrounds who share an interest in mathematics, software, or data. Some problems that have captured my interest include network analysis for cyber defense, and ...
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Email: rpr@wpi.edu
Phone: +1 (508) 8315000 x6120
A member of the WPI faculty since 2004 and chair of the Department of Biology and Biotechnology since 2022, Reeta Rao is a leader in the field of molecular genetics and genomics. Her primary research activities are focused on emerging infectious diseases, specifically understanding and managing fungal diseases. Students and research associates in her laboratory are trained to use a variety of biochemical, molecular-genetic, and genomic tools to study host-microbe interactions to explore fungal virulence strategies and identify novel therapeutics in a high throughput fashion. ...
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Email: sshell@wpi.edu
Phone: +1 (508) 8315000 x5917
I have a passion for understanding how living systems work, as well as for sharing my love of biology and research with the next generation of scientists and informed citizens.The central goal of my lab is to understand the regulatory mechanisms that underlie mycobacterial stress tolerance. We combine genetics, genomics, transcriptomics and biochemistry to understand how mycobacteria respond to, and ultimately survive, stressful conditions.Our guiding principles are curiosity, respect, and scientific rigor. Together we strive to push the boundaries of knowledge and advance our field by ...
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Email: jsrinivasan@wpi.edu
Phone: +1 (508) 8315000 x6564
It has been my lifelong dream to become a professor in the field of Biology. Being a faculty member provides a great opportunity to teach and interact with students. Students by nature are highly inquisitive and motivated, and as teachers, we have the responsibility to guide our students to explore and think in new ways. I believe that teaching is a two-way interaction between teachers and students. I come from India and my parents, both of whom were teachers, taught me to strive for excellence in my scholarly pursuits. Science bears no geographical barriers and my academic training has taken ...
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Email: qwen@wpi.edu
Phone: +1 (508) 8315000 x4932
Professor Wen is an experimental biophysicist who is interested in applying physical methods to understand biological phenomena. By measuring the mechanical properties of living cells and the mechanical interaction between cells and ECM, he aims to understand how cells convert external mechanical signals to internal biochemical signals that govern cellular function, including cell morphology, migration, and differentiation. His research will help to design novel materials for wound healing, tissue engineering, and tumor treatment.Professor Wen is leading a research group with students from ...
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Email: mwu2@wpi.edu
Phone: +1 (508) 8315000 x6377
My research involves analysing size and shape development in biological processes. The form of living systems can be affected by growth and internal force, so it is important to know how they are patterned spatial-temporally. To do this, I develop deterministic approximate inference schemes using static and live imaging data; and develop mathematical models and numerical methods to describe tissue growth and morphogenesis. My research at WPI has attracted interest from all levels of students, and they have become enthusiastic and creative contributors.
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Email: zheyangwu@wpi.edu
Phone: +1 (508) 8315000 x5031
Professor Wu's research interest lies in applying the power of statistical science to promote biomedical researches. In statistical genetics, he is developing novel statistical theory and methodology to analyze genome-wide association (GWA) data and deep (re)sequencing data to hunt new genetic factors for complex human diseases. In epigenetics, he is studying gene expression regulation mechanisms through chromatin interaction, and RNA silencing pathways in the developmental stages of germ-line cells. In clinical studies, he is establishing statistical models to predict carotid atherosclerotic ...
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BCB Staff
Email: nzhang3@wpi.edu
Phone: +1 (508) 8315000 x6677
I am an Administrative Assistant for the Computer Science Department and Bioinformatics & Computational Biology (BCB Program). My responsibility includes working with Department Heads and faculty with undergraduate administrative assistants, purchasing, hourly hiring, timesheet approval, and building/lab access. Before joining WPI, I was an independent college counselor assisting students with their undergraduate and graduate applications. I also held several software engineering positions, including 16 years as a principal software developer at Dell EMC Corporation. I obtained a ...
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