Gateway Park 4011
+1 (508) 8315000 x4145
BS Brown University 1995
PhD University of Washington 2003
Postdoc Benaroya Research Institute 2004-2007

In my research laboratory at WPI, teams of graduate and undergraduate students collaborate with researchers at WPI and the University of Massachusetts Medical School to design, fabricate, culture and analyze cell-based engineered vascular tissue. I enjoy collaborating with students to explore the role of cells and ECM on tissue organization and material properties in health and disease, and working with undergraduate student teams to apply engineering principles to design and prototype bioreactors that impart mechanical stimuli on engineered vascular tissues to simulate the hemodynamic environment of the human circulatory system. In the classroom, I frequently rely on my experience as a research scientist in a biomaterials and drug delivery group at a medical device company to educate and excite students about the challenges of bringing cell and molecular therapies from research concept to commercialization and clinical use.

Scholarly Work

2014 TERMIS-AM Conference Washington, DC December 13–16, 2014 S Kakinoki, M Nakayama, T Moritan, T Yamaoka, E Daley, J Stegemann, ... Tissue Engineering Part A 20 (S1), S-1-S-140
Methods of generating small-diameter tissue engineered blood vessels M Rolle, DP Parekh, KJ Doshi, T Gwyther US Patent App. 12/752,708
Cellular Therapies for Myocardial Infarct Repair CE Murry, ML Whitney, MA Laflamme, H Reinecke, LJ Field Cold Spring Harbor Symposia on Quantitative Biology 67, 519-526
Tissue-Engineered Vascular Rings from Human iPSC-Derived Smooth Muscle Cells BC Dash, K Levi, J Schwan, J Luo, O Bartulos, H Wu, C Qiu, T Yi, Y Ren, ... Stem Cell Reports 7 (1), 19-28
Effects of cyclic stretch on three-dimensional vascular smooth muscle cell rings JL Cooper, JT Favreau, GR Gaudette, MW Rolle 2014 40th Annual Northeast Bioengineering Conference (NEBEC), 1-2
Synthesis and organization of hyaluronan and versican by embryonic stem cells undergoing embryoid body differentiation S Shukla, R Nair, MW Rolle, KR Braun, CK Chan, PY Johnson, TN Wight, ... Journal of Histochemistry & Cytochemistry 58 (4), 345-358
Professional Highlights & Honors
Ruth L. Kirschstein National Research Service Award
National Heart, Lung and Blood Institute, National Institutes of Health
Sigma Xi Junior Faculty Researcher Award
Young Innovators in Biomedical Engineering Lecture
Georgia Institute of Technology
Board of Trustees’ Award for Outstanding Academic Advising
WBUR 90.9
Engineers Creating Diseased Blood Vessels to Test Medications

WBUR reported on research by Marsha Rolle, associate professor of biomedical engineering, spoke to WBUR about her work to develop self-assembling human blood vessels that exhibit the symptoms of common cardiovascular conditions. The engineered blood vessels may give scientists a better way to test the effectiveness of new medications.