My research in applied mathematics is in the field of inverse problems and uncertainty quantification, which involves estimating unknown system parameters using indirect observations and analyzing the changes in predicted outcomes due to changes in the inputs. In particular, I am interested in the design and analysis of efficient and robust nonlinear filtering algorithms for state and parameter estimation within a Bayesian inference framework and the application of such algorithms in analyzing real-world data. Please see my personal website for more information. View Profile

I compose, perform, record, mix and produce electroacoustic music; I am interested in how we can use the tools and techniques of audio production to explore new musical territory. I build mechatronic and robotic musical instruments; I am interested in how we can free electronic music from the world of speakers through computer-controlled automatic mechanical instruments. I conduct research and experiments that explore how our cognitive and perceptual processes affect our musical experience; I am interested in how we can use such research to guide our compositional and analytic activities. ... View Profile

Understanding the mechanisms by which mechanical forces regulate the development and healing of connective tissues and the pathogenesis of disease is becoming one of the foremost problems at the intersection of biomechanics and cell biology—it has spawned the field of mechanobiology. In our lab we use precisely engineered, two-dimensional and three-dimensional constructs as model systems to study the effects of external internal (cell-generated) forces on cell behavior, matrix biochemistry, and the biomechanics of soft tissues and biomaterials. ... View Profile

My research is in the area of Partial Differential Equations. I am also interested in Calculus of Variations and in analytic aspects of Quasiconformal Mappings, Sub-Riemannian Geometry, Minimal Surfaces and Mean Curvature Flow. Partial differential equations, and more in general Mathematics, provide a powerful language to express our understanding of complex phenomena in nature and in other contexts. The equilibrium and tension between pure mathematics and the applications that have motivated it is a source of never ending discovery and fascination for me. ... View Profile

Our lab investigates the molecular basis of phenotype switching in human fibroblasts that can be modulated using defined extracellular stimuli. We evaluate the role of oxygen and growth factor FGF2 isoforms independently and in combination in order to identify key molecular mechanisms and pathways, some of which closely mimic mechanisms described in human embryonic stem cells. Extended lifespan of these cells in culture also offers us a model for investigation of molecular mechanism that are regulating cell cycle in the context of both aging and cancer. ... View Profile

Since arriving at WPI in 1990, I have framed my role in the classroom as helping technically-minded students to become more cognizant and mindful of the complex human and behavioral dimensions of life in organizations. I have done this in a variety of ways from experiential exercises to digital storytelling to classroom-as-organization designs. ... View Profile

My research interests broadly focus on the molecular biology of mRNA translational control – or more simply put, “why” and “how” cells regulate the translation of their mRNAs into proteins. I am particularly interested in translational control as it relates to the cellular stress response. When cells are stressed by environmental factors, such as energy deprivation, heavy metal poisoning, or extreme temperatures, they will conserve resources by restricting mRNA translation. ... View Profile

My research interests lie in the broad area of circuits and systems, and my primary area of interest is analog/mixed signal integrated circuits. More specifically, I am interested in the circuit design of sensing interfaces and energy harvesting and wireless power transmission systems for applications in the IoT. Exponential increases in the demand for next-generation clinical and telemedical diagnostic devices require monitoring and measurements from inside and outside of the body via implantable and wearable sensors predicted to be an important pillar of smart healthcare. ... View Profile

I am a mathematical physicist working on the development and application of mathematical methods to atmospheric research and satellites orbits. As part of this research, I am also developing new methods for the use of symmetry principles to solve differential equations. I have taught a broad spectrum of applied math courses on the undergraduate and graduate levels. View Profile

My research interest focuses on developing quantitative live cell imaging methodologies to characterize dynamics and coordination of molecular/cellular events related with cytoskeleton organization and dynamics. Using these methods, my lab studies how cells sense, react, and harness mechanic forces in physiological/pathophysiological processes such as brain development and cancer metastasis. Ultimately, I want to develop novel therapeutics based on our mechanobiological understanding of cellular processes. I enjoy working together with students in both classroom and laboratory settings. ... View Profile

Carolina Ruiz's research interests are in machine learning, artificial intelligence and data mining. Together with her graduate and undergraduate students, Dr. Ruiz has worked on numerous interdisciplinary research projects with clinicians from the University of Massachusetts Medical School on developing and using machine learning algorithms over clinical and behavioral patient data. ... View Profile

I have been teaching and conducting research at WPI since 1988. Teaching is a lot of fun since it involves interactions with students, and we can pass our knowledge and experiences to students for their better future. I have been conducting research for cardiovascular modeling in the past 30 years and has made various contributions, especially in using image-based modeling for vulnerable plaque progression and rupture investigations. I collaborate with faculty from many universities, including Harvard, MIT, University of Washington (Seattle), Washington University (St. ... View Profile

My research has primarily focused on Internet application performance and measurement with more recent work examining issues related to Internet privacy. This work has led to a number of research publications and presentations as well as visibility in venues such as the New York Times, Wall Street Journal and NPR Science Friday. WPI is a great place for me to be a faculty member as I have the opportunity to teach and advise top-quality students as well as pursue interesting directions of research. ... View Profile

Professor Wu's research interest lies in applying the power of statistical science to promote biomedical researches. In statistical genetics, he is developing novel statistical theory and methodology to analyze genome-wide association (GWA) data and deep (re)sequencing data to hunt new genetic factors for complex human diseases. In epigenetics, he is studying gene expression regulation mechanisms through chromatin interaction, and RNA silencing pathways in the developmental stages of germ-line cells. ... View Profile